V
Victoria E. H. Wang
Researcher at Massachusetts Institute of Technology
Publications - 5
Citations - 371
Victoria E. H. Wang is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Host cell factor C1 & Transcription factor. The author has an hindex of 5, co-authored 5 publications receiving 361 citations.
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Journal ArticleDOI
The octamer binding transcription factor Oct-1 is a stress sensor
TL;DR: Results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress, including many associated with oxidative and metabolic stress.
Journal ArticleDOI
A YAC-based physical map of the mouse genome.
Chad Nusbaum,Donna K. Slonim,Katrina Harris,Bruce W. Birren,Robert G. Steen,Lincoln Stein,Joyce C. Miller,William F. Dietrich,Robert Nahf,Victoria E. H. Wang,Olga Merport,Andrew B. Castle,Zeeshan Husain,Gail Farino,Delphine Gray,Mechele O. Anderson,Richard Devine,Lloyd T. Horton,Wenjuan Ye,Xiaoyun Wu,Vardouhie Kouyoumjian,Irina S. Zemsteva,Yi Wu,Alville Collymore,Dorothy F. Courtney,James Tam,Matthew Cadman,Andrew R. Haynes,Christine Heuston,Tracy Marsland,Anne Southwell,Pamela Trickett,Mark A. Strivens,Mark T. Ross,Wojciech Makalowski,Yixun Xu,Yixun Xu,Mark S. Boguski,Nigel P. Carter,Paul Denny,Steve D.M. Brown,Thomas J. Hudson,Thomas J. Hudson,Eric S. Lander +43 more
TL;DR: Use of this map in addition to a newly constructed radiation hybrid (RH) map provides a comprehensive framework for mouse genomic studies, and directly facilitates positional cloning of mouse mutations by providing ready access to most of the genome.
Journal ArticleDOI
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.
TL;DR: A critical role for Oct-1 during development and a stringent gene dosage effect with Oct-2 in mediating postnatal survival are suggested.
Journal ArticleDOI
Herpes simplex virus infections are arrested in Oct-1-deficient cells.
Maurício Lacerda Nogueira,Victoria E. H. Wang,Dean Tantin,Phillip A. Sharp,Thomas M. Kristie +4 more
TL;DR: Surprisingly, whereas the viral IE genes are expressed after high moi infection ofOct-1-deficient cells, the assembly of viral replication factories is severely impaired, revealing a second critical role for Oct-1 in HSV replication.
Journal ArticleDOI
B cell development and immunoglobulin transcription in Oct-1-deficient mice
TL;DR: The lymphoid compartment of RAG-1–/– animals was reconstituted with Oct-1-deficient fetal liver hematopoietic cells and found that recipient mice develop B cells with levels of surface Ig expression comparable with wild type, although at slightly reduced numbers.