Mark A. Strivens

TL;DR: A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.

TL;DR: The results demonstrate that Bpa and Str are allelic mutations and identify the first mammalian locus associated with an X-linked dominant, male-lethal phenotype, and expand the spectrum of phenotypes associated with abnormalities of cholesterol metabolism.

TL;DR: A major ENU mutagenesis program incorporating a large genome-wide screen for dominant mutations and an improved mutant map of the mouse is begun, providing an extensive new resource of mutant and phenotype data to the mouse and human genetics communities at large.

TL;DR: Use of this map in addition to a newly constructed radiation hybrid (RH) map provides a comprehensive framework for mouse genomic studies, and directly facilitates positional cloning of mouse mutations by providing ready access to most of the genome.

TL;DR: This study provides a comprehensive analysis of DNA methylation and histone H3K4me3 and H3k9me3 modifications at imprinted gene clusters, and identifies common epigenetic and genetic features of regions regulating genomic imprinting.