Viktor Hornak

TL;DR: An effort to improve the φ/ψ dihedral terms in the ff99 energy function achieves a better balance of secondary structure elements as judged by improved distribution of backbone dihedrals for glycine and alanine with respect to PDB survey data.

TL;DR: The data strongly support the hypothesis that the unliganded protease predominantly populates the semiopen conformation, with closed and fully open structures being a minor component of the overall ensemble.

TL;DR: The K state, an early intermediate of the bacteriorhodopsin photocycle, is produced in crystals in a photostationary state at 100K, with 40% yield, and its X-ray diffraction structure is determined to 1.43 A resolution.

TL;DR: NMR measurements reveal that structural changes in EL2 are coupled to the motion of helix H5 and breaking of the ionic lock that regulates activation in this prototypical G protein–coupled receptor.

TL;DR: Solid-state magic angle spinning NMR measurements are presented that support the proposal that interaction of Trp 265 with the retinal chromophore is responsible for stabilizing an inactive conformation in the dark, and that motion of the beta-ionone ring allows Trp265(6.48) and transmembrane helix H6 to adopt active conformations in the light.