Vinay Kumar Nandicoori

TL;DR: It is shown that Rv1988, a secreted mycobacterial protein, is a functional methyltransferase that localizes to the host nucleus and interacts with chromatin that methylates histone H3 at H3R42 and represses the genes involved in the first line of defence againstMycobacteria.

TL;DR: It is demonstrated that although PknB-mediated phosphorylation of GlmU does not affect its uridyl transferase activity, it significantly modulates the acetyltransferase activity.

TL;DR: A novel enzymatic method involving an unprecedented sortase-catalyzed transamidation reaction for site-specific engineering of sugars into native proteins and it is shown that sugars appended with a 6-aminohexose moiety can be efficiently ligated to peptides and proteins encoded with a LPXTG sortase recognition sequence.

TL;DR: The present study describes the comprehensive analysis of different domains of PknB in the context of viability in avirulent and virulent mycobacteria, finding stringent regulation of P KnB expression necessary for cell survival, with depletion or overexpression of PKnB leading to cell death.

TL;DR: This is the first study that identifies a protein from a pathogenic bacteria with potential to influence host DNA methylation in a non-canonical manner providing the pathogen with a novel mechanism to alter the host epigenetic machinery.