V
Vincent C. Hascall
Researcher at Cleveland Clinic
Publications - 206
Citations - 13815
Vincent C. Hascall is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Hyaluronic acid & Proteoglycan. The author has an hindex of 64, co-authored 193 publications receiving 12685 citations. Previous affiliations of Vincent C. Hascall include Abbott Northwestern Hospital & Shriners Hospitals for Children.
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Journal ArticleDOI
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer
TL;DR: The roles of HA interactions with CD44 and RHAMM in inflammatory responses and tumor development/progression are described, and how therapeutic strategies that block these key inflammatory/tumorigenic processes may be developed in rodent and human diseases are described.
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Aggregation of Cartilage Proteoglycans I. THE ROLE OF HYALURONIC ACID
TL;DR: Evidence is presented which suggests that the hyaluronic acid-proteoglycan interactions described by Hardingham and Muir ((1972) Biochim.
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Hyaluronan binding by cell surface cd44
TL;DR: It is shown that hyaluronan binding at the cell surface is a complex interplay of multivalent binding events affected by the size of the multivalent hyaluranan ligand, the quantity and density of cell surface CD44, and the activation state of CD44 as determined by cell-specific factors and/or treatment with CD44-specific monoclonal antibody (mAb).
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Aggregation of Cartilage Proteoglycans: III. CHARACTERISTICS OF THE PROTEINS ISOLATED FROM TRYPSIN DIGESTS OF AGGREGATES
TL;DR: Experiments with aggregate preparations reconstituted from mixtures with [3H]acetylated or unlabeled proteoglycans showed that the larger protein fraction is derived from a portion of the protein in the proteoglycan monomer molecules while the smaller isderived from one of the small molecular weight "link proteins" that are present in proteogly can aggregate preparations.
Journal ArticleDOI
Hyaluronan–CD44 interactions as potential targets for cancer therapy
Suniti Misra,Paraskevi Heldin,Vincent C. Hascall,Nikos K. Karamanos,Spyros S. Skandalis,Roger R. Markwald,Shibnath Ghatak +6 more
TL;DR: The potential involvement of CD44 variants (CD44v4-v7 and CD44v6-v9) in tumor progression has been confirmed for many tumor types in numerous clinical studies as mentioned in this paper.