V
Vincent Chan
Researcher at University of Ottawa
Publications - 236
Citations - 11030
Vincent Chan is an academic researcher from University of Ottawa. The author has contributed to research in topics: Mitral valve & Adhesion. The author has an hindex of 43, co-authored 221 publications receiving 7917 citations. Previous affiliations of Vincent Chan include Wuhan Institute of Technology & University of Pennsylvania.
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Journal ArticleDOI
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
Journal ArticleDOI
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Kevin C. Barry,Joy Hsu,Miranda Broz,Francisco J. Cueto,Francisco J. Cueto,Francisco J. Cueto,Mikhail Binnewies,Alexis J. Combes,Amanda E. Nelson,Kimberly Loo,Raj Kumar,Michael Rosenblum,Michael Alvarado,Denise M. Wolf,Dusan Bogunovic,Nina Bhardwaj,Adil Daud,Patrick K. Ha,William R. Ryan,Joshua L. Pollack,Bushra Samad,Saurabh Asthana,Vincent Chan,Matthew F. Krummel +23 more
TL;DR: The studies reveal that innate immune SDCs and NK cells cluster together as an excellent prognostic tool for T cell–directed immunotherapy and that these innate cells are necessary for enhanced T cell tumor responses, suggesting this axis as a target for new therapies.
Journal ArticleDOI
Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation.
TL;DR: Cell-encapsulated hydrogels with complex three-dimensional structures were fabricated from photopolymerizable poly(ethylene glycol) diacrylate (PEGDA), and the feasibility of depositing multiple cell types and material compositions into distinct layers was established.
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Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T cell Immunity
Mikhail Binnewies,Adriana M. Mujal,Joshua L. Pollack,Alexis J. Combes,Emily A. Hardison,Kevin C. Barry,Jessica Tsui,Megan K. Ruhland,Kelly Kersten,Marwan Abushawish,Marko Spasic,Jonathan P. Giurintano,Vincent Chan,Adil Daud,Patrick K. Ha,Chun Jimmie Ye,Edward W. Roberts,Matthew F. Krummel +17 more
TL;DR: This work comprehensively characterized myeloid cells in tumor draining lymph nodes of mice and identified two subsets of conventional type-2 dendritic cells (cDC2) that traffic from tumor to tdLN and present tumor-derived antigens to CD4+ Tconv, but then fail to support antitumor CD4-Tconv differentiation.
Journal ArticleDOI
Three-dimensionally printed biological machines powered by skeletal muscle
Caroline Cvetkovic,Ritu Raman,Vincent Chan,Vincent Chan,Brian J. Williams,Madeline Tolish,Piyush Bajaj,Mahmut Selman Sakar,H. Harry Asada,M. Taher A. Saif,Rashid Bashir +10 more
TL;DR: 3D printed hydrogel “bio-bots” with an asymmetric physical design and powered by the actuation of an engineered mammalian skeletal muscle strip to result in net locomotion of the bio-bot are developed.