Showing papers by "Vincent Cogliano published in 2016"
Book•
01 Jan 2016
TL;DR: In this article, the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (WG-7) presented a review of polychlorinated biphenyls and polybrominated biphexyls.
Abstract: Polychlorinated biphenyls and polybrominated biphenyls. Volume 107. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
108 citations
Johns Hopkins University1, American Chemistry Council2, United States Environmental Protection Agency3, Center for Food Safety and Applied Nutrition4, ExxonMobil5, George Washington University6, Alternatives7, University of Konstanz8, Environmental Defense Fund9, National Institutes of Health10, European Food Safety Authority11
TL;DR: It is recommended that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematicreview methods are applied in toxicology.
48 citations
TL;DR: The evolution of understanding in assessments of the cancer and noncancer effects of PCBs is discussed, identifying where a lack of data in the past contributed to significant uncertainty and where new data subsequently altered the prevailing understanding of the toxicity of PCB mixtures, either qualitatively or quantitatively.
Abstract: Health risk assessments generally involve many extrapolations: for example, from animals to humans or from high doses to lower doses. Health risk assessments for PCBs involve all the usual uncertainties, plus additional uncertainties due to the nature of PCBs as a dynamic, complex mixture. Environmental processes alter PCB mixtures after release into the environment, so that people are exposed to mixtures that might not resemble the mixtures where there are toxicity data. This paper discusses the evolution of understanding in assessments of the cancer and noncancer effects of PCBs. It identifies where a lack of data in the past contributed to significant uncertainty and where new data subsequently altered the prevailing understanding of the toxicity of PCB mixtures, either qualitatively or quantitatively. Finally, the paper identifies some uncertainties remaining for current PCB health assessments, particularly those that result from a lack of data on exposure through nursing or on effects from inhalation of PCBs.
5 citations