Vincent M. Lam

TL;DR: This review discusses in detail the application of BRET to study dopamine and trace amine receptors signaling, presenting examples of an exchange protein activated by cAMP biosensor to measure cAMP, β-arrestin biosensors to determine β-Arrestin recruitment to the receptor, and dopamine D2 receptor and Trace amine-associated receptor 1 biosensor to investigate heterodimerization between them.

TL;DR: Both drugs rescue DAT maturation and functional activity of the DTDS-associated mutations A314V and R445C, which are the first demonstration of pharmacological chaperoning of DAT and suggest this may be a viable approach to increase DAT levels in DTDS and other conditions associated with reduced DAT function.

TL;DR: It is indicated that TAar1 is a negative regulator of dopamine transmission making TAAR1 a novel target for neuropsychiatric disorders that arises from dopamine dysfunction such as schizophrenia.

TL;DR: A quantitative, one‐step and potentially high‐throughput assay, using the β‐lactamase enzyme (βlac) as a reporter, for measurement of surface expression of proteins, applied to two G‐protein‐coupled receptors and a monoamine transporter.

TL;DR: Findings indicate that structural differences between salvinorin A and U69593 do not affect the potentiation of quinpirole sensitization, and the opposite effects of high and low salvinOrin A doses suggest that salvin orin A can produce bidirectional modulation of sensitization to dopamine agonists.