V
Vincent W. Bloks
Researcher at University Medical Center Groningen
Publications - 105
Citations - 8259
Vincent W. Bloks is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Cholesterol & Liver X receptor. The author has an hindex of 38, co-authored 93 publications receiving 7200 citations. Previous affiliations of Vincent W. Bloks include Leiden University Medical Center & University of Groningen.
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Journal ArticleDOI
Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome
A. Vrieze,Els van Nood,Frits Holleman,Jarkko Salojärvi,Ruud S. Kootte,Joep F. Bartelsman,Geesje M. Dallinga-Thie,Mariëtte T. Ackermans,Mireille J. Serlie,Raish Oozeer,Muriel Derrien,Anne Druesne,Johan E. T. van Hylckama Vlieg,Vincent W. Bloks,Albert K. Groen,Hans G.H.J. Heilig,Erwin G. Zoetendal,Erik S.G. Stroes,Willem M. de Vos,Willem M. de Vos,Joost B. L. Hoekstra,Max Nieuwdorp +21 more
TL;DR: Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans.
Journal ArticleDOI
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
Aldo Grefhorst,Baukje M Elzinga,Peter J. Voshol,Torsten Plösch,Tineke Kok,Vincent W. Bloks,Fjodor H. van der Sluijs,Louis M. Havekes,Johannes A. Romijn,Henkjan J. Verkade,Folkert Kuipers +10 more
TL;DR: It is concluded that, in addition to raising high density lipoprotein cholesterol concentrations, pharmacological LXR activation in mice leads to development of hepatic steatosis and secretion of atherogenic, large TG-rich VLDL particles.
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles Chapter 3
Aldo Grefhorst,Baukje M Elzinga,Peter J. Voshol,Torsten Plösch,Tineke Kok,Vincent W. Bloks,Fjodor H. van der Sluijs,Louis M. Havekes,Johannes A. Romijn,Henkjan J. Verkade,Folkert Kuipers +10 more
TL;DR: In this paper, the oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription of lipogenic genes.
Journal ArticleDOI
Beyond intestinal soap—bile acids in metabolic control
TL;DR: An overview of the molecular mechanisms by which bile acids modulate glucose and energy metabolism is provided, particularly focusing on the glucose-lowering actions of bile acid sequestrants in insulin resistant states and T2DM.
Journal ArticleDOI
24(s)-hydroxycholesterol participates in a liver x receptor- controlled pathway in astrocytes that regulates apolipoprotein e-mediated cholesterol efflux
Karlygash Abildayeva,Paula J. Jansen,Veronica Hirsch-Reinshagen,Vincent W. Bloks,Arjen H.F. Bakker,Frans C. S. Ramaekers,Jan de Vente,Albert K. Groen,Cheryl L. Wellington,Folkert Kuipers,Monique T. Mulder +10 more
TL;DR: Evidence is provided that 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway, which may be relevant for chronic and acute neurological diseases.