V
Vincenza Leone
Researcher at University of Naples Federico II
Publications - 27
Citations - 1656
Vincenza Leone is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Carcinogenesis & Thyroid carcinoma. The author has an hindex of 15, co-authored 24 publications receiving 1546 citations.
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Journal ArticleDOI
MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle.
Rosa Visone,Lucia Russo,Pierlorenzo Pallante,Ivana De Martino,Angelo Ferraro,Vincenza Leone,Eleonora Borbone,Fabio Petrocca,Hansjuerg Alder,Carlo M. Croce,Alfredo Fusco +10 more
TL;DR: The data reported here demonstrate that MiR-221 and miR-222 are endogenous regulators of p27(Kip1) protein expression, and thereby, the cell cycle.
Journal ArticleDOI
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Rosa Visone,Pierlorenzo Pallante,Andrea Vecchione,Roberto Cirombella,Manuela Ferracin,Angelo Ferraro,Stefano Volinia,Sabrina Coluzzi,Vincenza Leone,Eleonora Borbone,Chang Gong Liu,Fabio Petrocca,Giancarlo Troncone,George A. Calin,Aldo Scarpa,Chiara Colato,Giovanni Tallini,Massimo Santoro,Carlo M. Croce,Alfredo Fusco +19 more
TL;DR: Analysis of the microRNA profile of ATC in comparison to the normal thyroid using a microarray suggests a miR signature associated with ATC and suggests the miR deregulation as an important event in thyroid cell transformation.
Journal ArticleDOI
MiR-1 Is a Tumor Suppressor in Thyroid Carcinogenesis Targeting CCND2, CXCR4, and SDF-1α
Vincenza Leone,Daniela D'Angelo,Ileana G.S. Rubio,Paula Mussnich de Freitas,Antonella Federico,Marianna Colamaio,Pierlorenzo Pallante,Geraldo Medeiros-Neto,Alfredo Fusco +8 more
TL;DR: Functional studies demonstrate that miR-1 is able to inhibit thyroid carcinoma cell proliferation and migration, validating a role of mi R-1 down-regulation in thyroid carcinogenesis.
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Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer
Pierlorenzo Pallante,Antonella Federico,Maria Teresa Berlingieri,Mimma Bianco,Angelo Ferraro,Floriana Forzati,Antonino Iaccarino,Maria Giovanna Russo,Giovanna Maria Pierantoni,Vincenza Leone,Silvana Sacchetti,Giancarlo Troncone,Massimo Santoro,Alfredo Fusco +13 more
TL;DR: Restoration of CBX7 expression in thyroid cancer cells reduced growth rate, with a retention in the G(1) phase of the cell cycle, suggesting that CBx7 can contribute to the proliferation of the transformed thyroid cells.
Journal ArticleDOI
PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation.
Vincenza Leone,Antonella di Palma,Paolo Ricchi,Fabio Acquaviva,Maria Giannouli,Anna Maria Di Prisco,Francesca Iuliano,Angela Maria Acquaviva +7 more
TL;DR: It is demonstrated that PGE2 has the ability to increase Ras and PI3K association and decrease the level of apoptosis in the same experimental system, elucidate a novel mechanism for regulation of colon cancer cell survival and provide evidences for new combinatory treatments of Colon cancer.