V
Vinesh Vinayachandran
Researcher at Case Western Reserve University
Publications - 26
Citations - 1128
Vinesh Vinayachandran is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 10, co-authored 19 publications receiving 886 citations. Previous affiliations of Vinesh Vinayachandran include Council of Scientific and Industrial Research & University Hospitals of Cleveland.
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Journal ArticleDOI
Genome-wide nucleosome specificity and directionality of chromatin remodelers.
TL;DR: The genome-wide binding of remodeler complexes SWI/SNF, RSC,ISW1a, ISW1b, ISw2, and INO80 to individual nucleosomes in Saccharomyces is determined and their functional contributions to nucleosome positioning through deletion analysis are determined.
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SWR-C and INO80 Chromatin Remodelers Recognize Nucleosome-free Regions Near +1 Nucleosomes
TL;DR: These findings provide unifying concepts on how these two opposing chromatin remodeling complexes function selectively at the +1 nucleosome of nearly all genes.
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Molecular mechanisms of ribosomal protein gene coregulation.
TL;DR: It is suggested how sequence-specific DNA binding regulates nucleosome positioning and transcription complex assembly >300 bp away and how coregulation coevolved with coding sequences.
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The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression
Maren Schneider,Doris Hellerschmied,Tobias Schubert,Stefan Amlacher,Vinesh Vinayachandran,Rohit Reja,B. Franklin Pugh,Tim Clausen,Alwin Köhler +8 more
TL;DR: TREX-2 interacts with the Mediator complex, an essential regulator of RNA Polymerase (Pol) II, and uses its Mediator-interacting surface to regulate mRNA export suggesting a mechanism for coupling transcription initiation and early steps of mRNA processing.
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The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6.
S. Branden Van Oss,Margaret K. Shirra,Alain R. Bataille,Adam D. Wier,Kuangyu Yen,Kuangyu Yen,Vinesh Vinayachandran,In Ja L. Byeon,Christine E. Cucinotta,Annie Heroux,Jongcheol Jeon,Jae-Hoon Kim,Andrew P. VanDemark,B. Franklin Pugh,Karen M. Arndt +14 more
TL;DR: It is shown that the histone modification domain (HMD) of Paf1C subunit Rtf1 directly interacts with the ubiquitin conjugase Rad6 and stimulates H2Bub independently of transcription, arguing for an active role for Paf 1C in promoting H 2Bub and ensuring its proper localization in vivo.