Hoangdung Ho

TL;DR: A novel protein-engineering strategy is devised that overcomes the technical complexities of producing full-length human Nav channels and demonstrates how this important new class of gating modifier engages VSD4 to inhibit Nav channel activity through a “voltage-sensor trapping” mechanism.

TL;DR: A library consisting of most single transmembrane human receptors is built and a workflow for unbiased and high-sensitivity detection of receptor-ligand interactions is implemented to elucidate the long-sought receptor of human cytomegalovirus (HCMV), the leading viral cause of congenital birth defects.

TL;DR: A framework for the selective modulation of ABC transporters is established and provides rational avenues for the design of new antibiotics and other therapeutics targeting this protein family.

TL;DR: Two crystal structures of the human JAK1 FERM and SH2 domains bound to peptides derived from the class II cytokine receptors IFN-λ receptor 1 and IL-10 receptor 1 (IFNLR1 and IL10RA) are presented to identify a conserved JAK binding site for receptor peptides and elucidate the mechanism by which class II inflammation receptors interact with JAK 1.

TL;DR: A biochemical screen for inhibitors of MsbA was conducted and a series of quinoline compounds that kill Escherichia coli through inhibition of its ATPase and transport activity were identified, with no loss of activity against clinical multidrug-resistant strains.