Vivian L. Braciale

TL;DR: Treatment of the target cells with the lysosomotropic agent chloroquine abolished recognition of infected target cells by class II-restricted CTL without diminishing class I-restricted recognition ofinfected target cells, suggesting that important differences may exist in requirements for antigen presentation between H-2K/D and H- 2I region- restricted CTL.

TL;DR: The results directly implicate CTL as an important antiviral defense mechanism in experimental influenza infection and indicate that both the induction and expression of antiviral effector activity by CTL in vivo is highly specific and therefore favor the concept that CTL express their antiviralEffect in vivo by direct cytolysis of infected cells.

TL;DR: The authors' observations on the cellular immune response to type-A influenza suggest the existence of two distinct pathways of protein antigen presentation to T lymphocytes, one of which is involved with presentation of antigens introduced into the presenting cell from without and the second which is tentatively designated as an endogenous presentation pathway.

TL;DR: T cells recognize nonnative processed fragments of antigens presented in association with major histocompatibility complex (MHC) class I or class II molecules, and a cohesive model of MHC assembly and antigen presentation pathways is synthesized.

TL;DR: The cytotoxic effector function of the class II MHC-restricted CTL clones was mediated by direct lysis of virus-infected cells, and not by secretion of a cytolytic lymphokine.