V
Viviane Poupon
Researcher at Montreal Neurological Institute and Hospital
Publications - 16
Citations - 1275
Viviane Poupon is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Endocytic cycle & Endosome. The author has an hindex of 14, co-authored 16 publications receiving 1189 citations. Previous affiliations of Viviane Poupon include McGill University & Jewish General Hospital.
Papers
More filters
Journal ArticleDOI
Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation EVIDENCE FOR AN INTRACELLULAR ROUTE
Steve Poirier,Gaétan Mayer,Viviane Poupon,Peter S. McPherson,Roxane Desjardins,Kévin Ly,Marie-Claude Asselin,R Day,Franck Duclos,Mark R. Witmer,Rex A. Parker,Annik Prat,Nabil G. Seidah +12 more
TL;DR: It is shown that clathrin light chain small interfering RNAs that block intracellular trafficking from the trans-Golgi network to lysosomes rapidly increased LDLR levels within HepG2 cells in aPCSK9-dependent fashion without affecting the ability of exogenous PCSK9 to enhance LDLR degradation.
Journal ArticleDOI
Membrane dynamics and the biogenesis of lysosomes (Review)
J. Paul Luzio,Viviane Poupon,Margaret R. Lindsay,Barbara M. Mullock,Robert C. Piper,Paul R. Pryor +5 more
TL;DR: The present review focuses on current understanding of the molecular mechanisms of fusion of lysosomes with both endosomes and the plasma membrane and on the sorting events required for delivery of newly synthesized membrane proteins, endocytosed membrane proteins and other endocyTosed macromolecules to lysOSomes.
Journal ArticleDOI
Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.
TL;DR: Data indicate that the late Vps proteins function during multiple soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated fusion events throughout the endocytic pathway and that their activity may be coordinated with cytoskeletal function.
Journal ArticleDOI
Mapping of Eps15 domains involved in its targeting to clathrin-coated pits.
Alexandre Benmerah,Alexandre Benmerah,Viviane Poupon,Nadine Cerf-Bensussan,Alice Dautry-Varsat +4 more
TL;DR: It is shown that the N-terminal Eps15homology (EH) domains are required for CCP targeting but not sufficient, and that targeting of Eps15 to CCPs likely results from the collaboration between EH domains and another domain of the protein.
Journal ArticleDOI
Nucleocytoplasmic shuttling of endocytic proteins.
Manuela Vecchi,Simona Polo,Viviane Poupon,Jan Willem Van De Loo,Alexandre Benmerah,Pier Paolo Di Fiore,Pier Paolo Di Fiore +6 more
TL;DR: In the nucleus, eps15 and CALM acted as positive modulators of transcription in a GAL4-based transactivation assay, thus raising the intriguing possibility that some endocytic proteins play a direct or indirect role in transcriptional regulation.