Vlad Herlea

TL;DR: It is proved that the inhibition of an overexpressed UCR induces apoptosis in colon cancer cells, and the findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought.

TL;DR: A genetic variant of ARLTS1 predisposes patients to familial cancer, a member of the ADP-ribosylation factor family, with properties of a tumor-suppressor gene.

TL;DR: It is argued that ncRNAs are targeted by both germ line and somatic mutations as well as by single-nucleotide polymorphisms with functional significance for human tumorigenesis.

TL;DR: The data extend the spectrum of unstable microsatellites located in gene CDRs and suggest that BLM and possibly CBL are involved in gastrointestinal tumorigenesis.

TL;DR: It is suggested that Bloom syndrome BLM loss of function by MSI may increase the genetic instability of a pre-existent unstable genotype in gastric tumors.