Vladimir Mishin

TL;DR: It is reported that cotreatment with a second dietary component, piperine (from black pepper), enhanced the bioavailability of EGCG in mice and demonstrated the modulation of the E GCG bioavailablity by a second Dietary component and illustrates a mechanism for interactions between dietary chemicals.

TL;DR: A novel function for catalase is described potentially important in metabolism of endogenous substrates and in the action of carcinogens and chemopreventative agents.

TL;DR: It is demonstrated that cytochrome P450s are a major source of hydrogen peroxide in the recombinant cyto Chrome P450 monooxygenase system, and substrate binding is not required for the cy tochrome P 450s to generate reactive oxygen species.

TL;DR: Diquat redox cycling in CHO cells was associated with marked increases in protein carbonyl formation, a marker of protein oxidation, as well as cellular oxygen consumption, measured using oxygen microsensors; greater activity was detected in CHO-OR cells than in CHO

TL;DR: It is discovered that lung epithelial cells possess a distinct cytoplasmic diphenyleneiodonium-sensitive NAD(P)H:paraquat oxidoreductase, which utilizes oxygen, requires NADH or NADPH, and readily generates the reduced paraquat radical.