V
Volker Eckstein
Researcher at Heidelberg University
Publications - 92
Citations - 6934
Volker Eckstein is an academic researcher from Heidelberg University. The author has contributed to research in topics: CD34 & Haematopoiesis. The author has an hindex of 36, co-authored 88 publications receiving 6353 citations. Previous affiliations of Volker Eckstein include University Hospital Heidelberg.
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Journal ArticleDOI
Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells.
Laura Poisa-Beiro,Laura Poisa-Beiro,Judith Thoma,Judith Thoma,Jonathan J M Landry,Sven W. Sauer,Akihisa Yamamoto,Volker Eckstein,Natalie Romanov,Natalie Romanov,Simon Raffel,Georg F. Hoffmann,Peer Bork,Peer Bork,Vladimir Benes,Anne-Claude Gavin,Anne-Claude Gavin,Anne-Claude Gavin,Motomu Tanaka,Motomu Tanaka,Anthony D. Ho,Anthony D. Ho,Anthony D. Ho +22 more
TL;DR: It is concluded that upregulated glycolysis in aging HPCs is caused by the expansion of a more Glycolytic HPC subset, and isolation and mechanistic characterization of this subpopulation can be utilized to elucidate specific targets for therapeutic interventions to restore the lineage balance of aging H PCs.
Journal ArticleDOI
Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses.
Michael Schmitt,Anita Schmitt,Markus Wiesneth,Angela Hückelhoven,Zeguang Wu,Jürgen Kuball,Lei Wang,Peter Schauwecker,Susanne Hofmann,Susanne Hofmann,Marlies Götz,Birgit Michels,Birgit Maccari,Patrick Wuchter,Volker Eckstein,Thomas Mertens,Paul Schnitzler,Hartmut Döhner,Anthony D. Ho,Donald Bunjes,Peter Dreger,Hubert Schrezenmeier,Jochen Greiner +22 more
TL;DR: Humoral and cellular immune responses correlated with clearance of CMV, and vaccination for patients after allogeneic stem cell transplantation at high risk for CMV reactivation was safe, well tolerated and clinically encouraging.
Journal ArticleDOI
Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents
Cornelia Monzel,Cornelia Monzel,Alexandra S. Becker,Rainer Saffrich,Rainer Saffrich,Patrick Wuchter,Patrick Wuchter,Volker Eckstein,Anthony D. Ho,Motomu Tanaka,Motomu Tanaka +10 more
TL;DR: It is found that NOX-A12, an L-enantiomeric RNA oligonucleotide to SDF1, significantly reduced the adhesion of HSPC to the niche surface mediated via the CXCR4-SDF1α axis, and stretched the migration trajectories of the H SPC.
Book ChapterDOI
Identification and separation of normal hematopoietic stem cells and leukemia stem cells from patients with acute myeloid leukemia.
Van T. Hoang,Isabel Hoffmann,Karina Borowski,Abraham Zepeda-Moreno,Dan Ran,Eike C. Buss,Patrick Wuchter,Volker Eckstein,Anthony D. Ho +8 more
TL;DR: A flow cytometric method is devised for the identification and separation of these two stem cell populations based on surface antigen markers such as CD34, CD38, lineage aberrant markers, and aldehyde dehydrogenase (ALDH) enzyme activity.
Journal ArticleDOI
Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients
Matthias Schaier,Claudius Gottschalk,Lorenz Uhlmann,Claudius Speer,Florian Kälble,Volker Eckstein,Carsten Müller-Tidow,Stefan Meuer,Karsten Mahnke,Hanns-Martin Lorenz,Martin Zeier,Andrea Steinborn +11 more
TL;DR: Testing the Tregs of healthy volunteers and SLE patients with autologous and nonautologous Tresps revealed that the significantly decreased Treg function in Sle patients was not exclusively attributed to an age-dependent diminished sensitivity of the TresPS for Treg suppression, and the currently used immunosuppressive therapy has a favorable effect on the differentiation and proliferation of TResps but has a rather unfavorable effect on Theregs.