V
Vu Thuy Khanh Le-Trilling
Researcher at University of Duisburg-Essen
Publications - 53
Citations - 1030
Vu Thuy Khanh Le-Trilling is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Human cytomegalovirus & Medicine. The author has an hindex of 14, co-authored 42 publications receiving 627 citations. Previous affiliations of Vu Thuy Khanh Le-Trilling include Huazhong University of Science and Technology & University of Duisburg.
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Journal ArticleDOI
m 6 A modification controls the innate immune response to infection by targeting type I interferons
Roni Winkler,Ella Gillis,Lior Lasman,Modi Safra,Shay Geula,Clara Soyris,Aharon Nachshon,Julie Tai-Schmiedel,Nehemya Friedman,Nehemya Friedman,Vu Thuy Khanh Le-Trilling,Mirko Trilling,Michal Mandelboim,Michal Mandelboim,Jacob H. Hanna,Schraga Schwartz,Noam Stern-Ginossar +16 more
TL;DR: It is shown that following viral infection or stimulation of cells with an inactivated virus, deletion of the m6A ‘writer’ METTL3 or ‘reader’ YTHDF2 led to an increase in the induction of interferon-stimulated genes, and propagation of different viruses was suppressed in an interferON-signaling-dependent manner.
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The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions.
Osnat Tirosh,Yifat Cohen,Alina Shitrit,Odem Shani,Vu Thuy Khanh Le-Trilling,Mirko Trilling,Gilgi Friedlander,Marvin E. Tanenbaum,Noam Stern-Ginossar +8 more
TL;DR: By simultaneously examining the changes in transcription and translation along HCMV infection, this work uncover extensive transcriptional control that dominates the response to infection, but also diverse and dynamic translational regulation for subsets of host genes.
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Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
Tiziano Donnarumma,George R. Young,Julia Merkenschlager,Urszula Eksmond,Nadine Bongard,Stephen L. Nutt,Claude Boyer,Ulf Dittmer,Vu Thuy Khanh Le-Trilling,Mirko Trilling,Wibke Bayer,George Kassiotis,George Kassiotis +12 more
TL;DR: Using single-cell transcriptional profiling, a unique signature of Granzyme B (GzmB)+ CD4+ CTLs is uncovered, which distinguishes them from otherCD4+ T helper (Th) cells, including Th1 cells, and strongly contrasts with the follicular helper T (Tfh) cell signature.
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Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression
Dominik A. Megger,Dominik A. Megger,Jos Philipp,Vu Thuy Khanh Le-Trilling,Barbara Sitek,Mirko Trilling +5 more
TL;DR: A new class of IFN-repressed genes comprises known host factors for highly relevant pathogens such as HIV, dengue virus, and hepatitis C virus and its dynamics of protein induction and repression are revealed.
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Broad and potent antiviral activity of the NAE inhibitor MLN4924.
Vu Thuy Khanh Le-Trilling,Dominik A. Megger,Benjamin Katschinski,Christine D. Landsberg,Meike Rückborn,Sha Tao,Adalbert Krawczyk,Wibke Bayer,Ingo Drexler,Matthias Tenbusch,Barbara Sitek,Mirko Trilling +11 more
TL;DR: Global proteome analyses revealed that MLN4924 blocks cytomegaloviral replication despite increased IE1 amounts, and Expression of dominant negative Cullins assigned this IE regulation to defined Cullin molecules and phenocopied the antiviral effect of MLN 4924.