G
George Kassiotis
Researcher at Francis Crick Institute
Publications - 151
Citations - 9455
George Kassiotis is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 40, co-authored 121 publications receiving 7148 citations. Previous affiliations of George Kassiotis include Medical Research Council & Imperial College London.
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Journal ArticleDOI
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Séverine Boillée,Koji Yamanaka,Christian S. Lobsiger,Neal G. Copeland,Nancy A. Jenkins,George Kassiotis,George Kollias,Don W. Cleveland +7 more
TL;DR: Onset and progression of amyotrophic lateral sclerosis represent distinct disease phases defined by mutant action within different cell types to generate non–cell-autonomous killing of motor neurons; these findings validate therapies, including cell replacement, targeted to the non-neuronal cells.
Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination.
Emma C Wall,Emma C Wall,Emma C Wall,Mary Wu,Ruth Harvey,Gavin Kelly,Scott Warchal,Chelsea Sawyer,Rodney S. Daniels,Philip Hobson,Emine Hatipoglu,Yenting Ngai,Saira Hussain,Jerome Nicod,Robert J. Goldstone,Karen Ambrose,Steve Hindmarsh,Rupert Beale,Rupert Beale,Rupert Beale,Andrew Riddell,Steve Gamblin,Michael Howell,George Kassiotis,George Kassiotis,Vincenzo Libri,Vincenzo Libri,Vincenzo Libri,Bryan Williams,Bryan Williams,Bryan Williams,Charles Swanton,Sonia Gandhi,Sonia Gandhi,David L.V. Bauer +34 more
Journal ArticleDOI
Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level Implications for Pathogenesis and Therapy of Autoimmune Demyelination
George Kassiotis,George Kollias +1 more
TL;DR: A dual role for TNF is revealed in this study in experimental autoimmune encephalomyelitis (EAE), a mouse model for MS, and blocking the function of the p55 TNFR in autoimmune demyelination may inhibit the noxious proinflammatory activities of TNF without compromising its immunosuppressive properties.
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Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice: Models for Multiple Sclerosis with Primary Oligodendrogliopathy
Katerina Akassoglou,Jan Bauer,George Kassiotis,Manolis Pasparakis,Hans Lassmann,George Kollias,Lesley Probert +6 more
TL;DR: It is demonstrated that aberrant local TNF/p55TNF receptor signaling in the central nervous system can have a potentially major role in the aetiopathogenesis of MS demyelination, particularly in MS subtypes in which oligodendrocyte death is a primary pathological feature.