G
Gilgi Friedlander
Researcher at Weizmann Institute of Science
Publications - 42
Citations - 3064
Gilgi Friedlander is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 17, co-authored 34 publications receiving 2638 citations.
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Journal ArticleDOI
Revealing modular organization in the yeast transcriptional network
TL;DR: The approach assigns genes to context-dependent and potentially overlapping 'transcription modules', thus overcoming the main limitations of traditional clustering methods, and uses the method to elucidate regulatory properties of cellular pathways and to characterize cis-regulatory elements.
Journal ArticleDOI
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.
Ehud Zigmond,Chen Varol,Julia Farache,Elinor Elmaliah,Ansuman T. Satpathy,Gilgi Friedlander,Matthias Mack,Nahum Y. Shpigel,Ivo G. Boneca,Ivo G. Boneca,Kenneth M. Murphy,Guy Shakhar,Zamir Halpern,Steffen Jung +13 more
TL;DR: It is shown that CCR2 expression is essential to the recruitment of Ly6C(hi) monocytes to the inflamed gut to become the dominant mononuclear cell type in the lamina propria during settings of acute colitis.
Journal ArticleDOI
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Ehud Zigmond,Biana Bernshtein,Gilgi Friedlander,Catherine Walker,Simon Yona,Ki-Wook Kim,Ori Brenner,Rita Krauthgamer,Chen Varol,Werner Müller,Steffen Jung +10 more
TL;DR: IL-10 is highlighted as a critical homeostatic macrophage-conditioning agent in the colon and intestinal CX3CR1(hi) macrophages are defined as a decisive factor that determines gut health or inflammation.
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Simultaneous transcriptome analysis of Colletotrichum gloeosporioides and tomato fruit pathosystem reveals novel fungal pathogenicity and fruit defense strategies.
TL;DR: In this article, the fungus Colletotrichum gloeosporioides breaches the fruit cuticle but remains quiescent until fruit ripening signals a switch to necrotrophy, culminating in devastating anthracnose disease.
Journal ArticleDOI
Failure of the Tomato Trans-Acting Short Interfering RNA Program to Regulate AUXIN RESPONSE FACTOR3 and ARF4 Underlies the Wiry Leaf Syndrome
Tamar Yifhar,Irena Pekker,Dror Peled,Gilgi Friedlander,Anna Pistunov,Moti Sabban,Guy Wachsman,John Paul Alvarez,Ziva Amsellem,Yuval Eshed +9 more
TL;DR: In this paper, the authors show that trans-acting short interfering RNAs (ta-siRNAs) are a universal sensor for interference with small RNA biogenesis, and changes in their levels direct species-specific responses.