S
Schraga Schwartz
Researcher at Weizmann Institute of Science
Publications - 75
Citations - 14226
Schraga Schwartz is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: RNA & Exon. The author has an hindex of 37, co-authored 67 publications receiving 10658 citations. Previous affiliations of Schraga Schwartz include Broad Institute & Tel Aviv University.
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Journal ArticleDOI
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dan Dominissini,Sharon Moshitch-Moshkovitz,Schraga Schwartz,Schraga Schwartz,Mali Salmon-Divon,Lior Ungar,Sivan Osenberg,Sivan Osenberg,Karen Cesarkas,Jasmine Jacob-Hirsch,Ninette Amariglio,Martin Kupiec,Rotem Sorek,Gideon Rechavi,Gideon Rechavi +14 more
TL;DR: The findings suggest that RNA decoration by m6A has a fundamental role in regulation of gene expression, and a subset of stimulus-dependent, dynamically modulated sites is identified.
Journal ArticleDOI
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Alex K. Shalek,Rahul Satija,Xian Adiconis,Rona S. Gertner,Jellert T. Gaublomme,Raktima Raychowdhury,Schraga Schwartz,Nir Yosef,Christine M. Malboeuf,Diana Lu,John J. Trombetta,David Gennert,Andreas Gnirke,Alon Goren,Alon Goren,Nir Hacohen,Nir Hacohen,Joshua Z. Levin,Hongkun Park,Hongkun Park,Aviv Regev,Aviv Regev +21 more
TL;DR: The authors used single-cell RNA-Seq to investigate heterogeneity in the response of bone marrow derived dendritic cells (BMDCs) to lipopolysaccharide (LPS) and found extensive, and previously unobserved, bimodal variation in mRNA abundance and splicing patterns.
Journal ArticleDOI
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
Schraga Schwartz,Maxwell R. Mumbach,Marko Jovanovic,Timothy C. Wang,Timothy C. Wang,Karolina Maciag,Karolina Maciag,G. Guy Bushkin,Philipp Mertins,Dmitry Ter-Ovanesyan,Naomi Habib,Davide Cacchiarelli,Davide Cacchiarelli,Neville E. Sanjana,Elizaveta Freinkman,Michael E. Pacold,Michael E. Pacold,Rahul Satija,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Nir Hacohen,Nir Hacohen,Feng Zhang,Feng Zhang,Feng Zhang,Steven A. Carr,Eric S. Lander,Eric S. Lander,Eric S. Lander,Aviv Regev,Aviv Regev,Aviv Regev +31 more
TL;DR: A dense network of proteins interacting with METTL3, a component of the methyltransferase complex, is identified, and it is shown that three of them (WTAP, METTL14, and KIAA1429) are required for methylation.
Journal ArticleDOI
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
Alex K. Shalek,Rahul Satija,Joe Shuga,John J. Trombetta,David Gennert,Diana Lu,Peilin Chen,Rona S. Gertner,Jellert T. Gaublomme,Nir Yosef,Schraga Schwartz,Brian Fowler,Suzanne Weaver,Jing Wang,Xiaohui Wang,Ruihua Ding,Raktima Raychowdhury,Nir Friedman,Nir Hacohen,Hongkun Park,Andrew May,Aviv Regev +21 more
TL;DR: This study highlights the importance of cell-to-cell communication in controlling cellular heterogeneity and reveals general strategies that multicellular populations can use to establish complex dynamic responses.
Journal ArticleDOI
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schraga Schwartz,Douglas A. Bernstein,Maxwell R. Mumbach,Marko Jovanovic,Rebecca H. Herbst,Brian X. León-Ricardo,Jesse M. Engreitz,Mitchell Guttman,Rahul Satija,Eric S. Lander,Gerald R. Fink,Aviv Regev,Aviv Regev,Aviv Regev +13 more
TL;DR: In this paper, the authors develop Ψ-seq for transcriptome-wide quantitative mapping of pseudouridine and identify hundreds of unique sites in human and yeast mRNAs and snoRNAs.