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W. Kimryn Rathmell
Researcher at Vanderbilt University Medical Center
Publications - 229
Citations - 70647
W. Kimryn Rathmell is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Clear cell renal cell carcinoma & Cancer. The author has an hindex of 64, co-authored 200 publications receiving 54236 citations. Previous affiliations of W. Kimryn Rathmell include Stanford University & Vanderbilt University.
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Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response
TL;DR: The TCE-associated P81S VHL mutation can initiate a unique adaptive response required for selective tumor growth through pleiotropic effects on metabolic diversification, apoptosis suppression, and alteration of the DNA damage response.
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Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma.
David F. McDermott,Mahrukh Huseni,Michael B. Atkins,Robert J. Motzer,Brian I. Rini,Bernard Escudier,Lawrence Fong,Richard W. Joseph,Sumanta K. Pal,James A. Reeves,Mario Sznol,John D. Hainsworth,W. Kimryn Rathmell,Walter M. Stadler,Thomas E. Hutson,Martin Gore,Alain Ravaud,Sergio Bracarda,Cristina Suarez,Riccardo Danielli,Viktor Gruenwald,Toni K. Choueiri,Dorothee Nickles,Suchit Jhunjhunwala,Elisabeth Piault-Louis,Alpa Thobhani,Jiaheng Qiu,Daniel S. Chen,Priti S. Hegde,Christina Schiff,Gregg Fine,Thomas Powles +31 more
TL;DR: In the version of this article originally published, there was an error in Fig. 2n where the top line of the HR comparison chart originally was Atezo + bev vs sun.
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The therapeutic implications of immunosuppressive tumor aerobic glycolysis.
TL;DR: How founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis, which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche, promoting malignant cell proliferation, maintenance and progression is summarized.
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Receptor Tyrosine Kinase-like Orphan Receptor 2 (Ror2) Expression Creates a Poised State of Wnt Signaling in Renal Cancer
Neal R. Rasmussen,Tricia M. Wright,Samira A. Brooks,Kathryn E. Hacker,Zufan Debebe,Adam B. Sendor,Matthew P. Walker,Michael B. Major,Jennifer L. Green,Geoffrey M. Wahl,W. Kimryn Rathmell +10 more
TL;DR: Evidence is provided that Ror2 expression results in a partially activated state for canonical Wnt signaling through an increased signaling pool of β-catenin, leading to an enhancement of downstream target genes following Wnt3a stimulation in both renal and renal carcinoma-derived cells.
Journal ArticleDOI
Patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities☆
Scott M. Haake,Samira A. Brooks,Eric A. Welsh,William Fulp,Dung Tsa Chen,Jasreman Dhillon,Eric B. Haura,Wade J. Sexton,Philippe E. Spiess,Julio M. Pow-Sang,W. Kimryn Rathmell,Mayer Fishman +11 more
TL;DR: Obesity and diabetes mellitus emerged as factors that may influence ccRCC phenotypes and further studies investigating the effect of these metabolic conditions functionally onto tumor biology are warranted.