W
W. Kimryn Rathmell
Researcher at Vanderbilt University Medical Center
Publications - 229
Citations - 70647
W. Kimryn Rathmell is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Clear cell renal cell carcinoma & Cancer. The author has an hindex of 64, co-authored 200 publications receiving 54236 citations. Previous affiliations of W. Kimryn Rathmell include Stanford University & Vanderbilt University.
Papers
More filters
Journal ArticleDOI
A cytoskeletal function for PBRM1 reading methylated microtubules
Menuka Karki,Rahul K. Jangid,Ramakrishnan Anish,Riyad N.H. Seervai,Jean-Philippe Bertocchio,Jean-Philippe Bertocchio,Takashi Hotta,Pavlos Msaouel,Sung Yun Jung,Sandra L. Grimm,Cristian Coarfa,Bernard E. Weissman,Ryoma Ohi,Kristen J. Verhey,H. Courtney Hodges,Warren W. Burggren,Ruhee Dere,In Young Park,B. V. Venkataram Prasad,W. Kimryn Rathmell,Cheryl L. Walker,Durga Nand Tripathi +21 more
TL;DR: In this paper, the authors show that the coordinated read-write activity of the epigenetic machinery extends to the cytoskeleton, with PBRM1 in the PBAF chromatin remodeling complex reading microtubule methyl marks written by the SETD2 histone methyltransferase.
Journal ArticleDOI
Phase II Trial of 5-Fluorouracil and Leucovorin in Combination With Interferon-alpha and Interleukin-2 for Advanced Renal Cell Cancer
W. Kimryn Rathmell,S. Bruce Malkowicz,Christopher P. Holroyde,Will Luginbuhl,David J. Vaughn +4 more
TL;DR: This combination chemoimmunotherapy regimen has substantial toxicity but no significant antitumor activity in patients with advanced stage renal cell carcinoma.
Journal ArticleDOI
Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database--UNC GOLD.
Sarah A. Gallagher,Angela B. Smith,Jonathan Matthews,Clarence W. Potter,Michael Woods,Mathew C. Raynor,Eric Wallen,W. Kimryn Rathmell,Young E. Whang,William Y. Kim,Paul A. Godley,Ronald C. Chen,Andrew Z. Wang,Chaochen You,Daniel A. Barocas,Raj S. Pruthi,Matthew E. Nielsen,Matthew I. Milowsky +17 more
TL;DR: A discipline-specific database requires a buy-in from all stakeholders, meticulous development, and data entry resources to generate a unique platform for housing information that may be used for clinical care and research with IRB approval.
Journal ArticleDOI
Neoadjuvant pazopanib and molecular analysis of tissue response in renal cell carcinoma
Christopher G. Wood,James E. Ferguson,Joel S. Parker,Dominic T. Moore,Jennifer G. Whisenant,Susan J. Maygarden,Eric Wallen,William Y. Kim,Mathew I. Milowsky,Kathryn E. Beckermann,Nancy B. Davis,Scott M. Haake,Jose A. Karam,Dante S. Bortone,Benjamin G. Vincent,Thomas Powles,W. Kimryn Rathmell +16 more
TL;DR: Sequencing revealed strong concordance between pre- and posttreatment samples within individual tumors, suggesting tumors harbor stable core profiles, and pazopanib is safe and active in ccRCC.
Journal ArticleDOI
Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.
Matthias Koenning,Xianlong Wang,Menuka Karki,Rahul K. Jangid,Sarah Kearns,Durga Nand Tripathi,Michael A. Cianfrocco,Kristen J. Verhey,Sung Yun Jung,Cristian Coarfa,Christopher S. Ward,Brian T. Kalish,Sandra L. Grimm,W. Kimryn Rathmell,Ricardo Mostany,Ruhee Dere,Matthew N. Rasband,Cheryl L. Walker,In Young Park +18 more
TL;DR: In this article, the SETD2 α-tubulin lysine 40 trimethyl mark was found on microtubules in the brain and in primary neurons in culture, and it was shown that the SetD2 C-terminal SRI domain is required for binding and methylation of α -tubulin.