W. L. Whitter

TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.

TL;DR: In this article, 3.3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.

TL;DR: In this paper, a new method for the resolution of amines and its application to 3-aminobenzodiazepines was described, which involves the synthesis and separation of a pair of phenylalanyl amide diastereomers followed by removal of phenYLalanine via the Edman degradation to give the individual enantiomers of 1 with high chiral purities.

TL;DR: Coupling of the benzophenones (I) with D-tryptophan methyl ester hydrochloride (II) gives the benzodiazepinones (III) as mentioned in this paper.