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Yaw Shin Ooi
Researcher at Stanford University
Publications - 19
Citations - 1130
Yaw Shin Ooi is an academic researcher from Stanford University. The author has contributed to research in topics: Dengue virus & Viral replication. The author has an hindex of 12, co-authored 16 publications receiving 850 citations. Previous affiliations of Yaw Shin Ooi include Icahn School of Medicine at Mount Sinai & Albert Einstein College of Medicine.
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Journal ArticleDOI
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
Caleb D. Marceau,Andreas S. Puschnik,Karim Majzoub,Yaw Shin Ooi,Susan M. Brewer,Gabriele Fuchs,Kavya Swaminathan,Miguel A. Mata,Joshua E. Elias,Peter Sarnow,Jan E. Carette +10 more
TL;DR: A pooled CRISPR genetic screening strategy is used to comprehensively dissect host factors required for dengue virus and Hepatitis C virus, and finds an unexpected link between intracellular flavin adenine dinucleotide levels and HCV replication.
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A CRISPR toolbox to study virus-host interactions
TL;DR: The relative ease of use and reproducibility of CRISPR–Cas make it a powerful tool for probing virus–host interactions and for identifying new antiviral targets.
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SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Alex W. Wilkinson,Jonathan Diep,Shaobo Dai,Shuo Liu,Yaw Shin Ooi,Dan Song,Tie-Mei Li,John R. Horton,Xing Zhang,Chao Liu,Darshan V. Trivedi,Katherine M. Ruppel,Jose G. Vilches-Moure,Kerriann M. Casey,Justin Mak,Tina M. Cowan,Joshua E. Elias,Claude M. Nagamine,James A. Spudich,Xiaodong Cheng,Jan E. Carette,Or Gozani +21 more
TL;DR: SETD3 methylates mammalian actin at His73, and SETD3 deficiency impairs stimulus-induced contraction in primary human uterine smooth muscle cells and leads to maternal dystocia in mice, which supports the broader hypothesis that protein histidine methylation acts as a common regulatory mechanism.
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STR Data for the AmpFlSTR Identifiler loci in three ethnic groups (Malay, Chinese, Indian) of the Malaysian population.
Lay Hong Seah,N.Hithaya Jeevan,Mohd Izuan Othman,Primulapathi Jaya,Yaw Shin Ooi,Pui Cheng Wong,Sue Sing Kee +6 more
TL;DR: Allele frequencies for the 15 STR loci in the AmpF l STR Identifiler kit were determined and compared for the three main ethnic groups of the Malaysian population comprising 210 Malays, 219 Chinese and 209 Indians as discussed by the authors.
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Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry
TL;DR: Fuzzy homologue (FUZ), a protein with reported roles in planar cell polarity and cilia biogenesis, was required for the clathrin-dependent internalization of both alphaviruses and the classical endocytic ligand transferrin, and TSPAN9 was critical for the efficient fusion of low pH-triggered virus with the endosome membrane.