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Weiqiang Chen
Researcher at University of Southern California
Publications - 34
Citations - 1783
Weiqiang Chen is an academic researcher from University of Southern California. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 16, co-authored 26 publications receiving 1377 citations. Previous affiliations of Weiqiang Chen include Griffith University & Agency for Science, Technology and Research.
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Journal ArticleDOI
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.
Qiming Liang,Qiming Liang,Zhifei Luo,Jianxiong Zeng,Weiqiang Chen,Suan-Sin Foo,Shin-Ae Lee,Jianning Ge,Su Wang,Steven A. Goldman,Steven A. Goldman,Berislav V. Zlokovic,Zhen Zhao,Jae U. Jung +13 more
TL;DR: It is shown that ZIKV infection of human fetal neural stem cells (fNSCs) causes inhibition of the Akt-mTOR pathway, leading to defective neurogenesis and aberrant activation of autophagy, suggesting potential targets for anti-ZIKV therapeutic intervention.
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Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
Felicity J. Burt,Weiqiang Chen,Jonathan J. Miner,Deborah J. Lenschow,Andres Merits,Esther Schnettler,Alain Kohl,Penny A. Rudd,Adam Taylor,Lara J. Herrero,Ali Zaid,Lisa F. P. Ng,Lisa F. P. Ng,Suresh Mahalingam +13 more
TL;DR: An update on chikungunya virus with regard to its epidemiology, molecular virology, virus-host interactions, immunological responses, animal models, and potential antiviral therapies and vaccines is provided.
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Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets.
Su-Jin Park,Kwang-Min Yu,Young-Il Kim,Se Mi Kim,Eun-Ha Kim,Seong Gyu Kim,Eun Ji Kim,Mark Anthony B. Casel,Rare Rollon,Seung Gyu Jang,Min Hyeok Lee,Jae Hyung Chang,Min-Suk Song,Hye Won Jeong,Younho Choi,Weiqiang Chen,Woo Jin Shin,Jae U. Jung,Young Ki Choi +18 more
TL;DR: All antiviral drugs tested marginally reduced the overall clinical scores of infected ferrets but did not significantly affect in vivo virus titers.
Journal ArticleDOI
Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy.
Suan-Sin Foo,Weiqiang Chen,Yen Chan,James W. Bowman,Lin-Chun Chang,Younho Choi,Ji-Seung Yoo,Jianning Ge,Genhong Cheng,Alexandre Bonnin,Karin Nielsen-Saines,Patrícia Brasil,Jae U. Jung +12 more
TL;DR: Asian-lineage ZIKV infection of pregnant women’s blood led to an exacerbated M2-skewed immunosuppression of non-classical monocytes in conjunction with a global suppression of type I interferon-signalling pathway and an aberrant expression of host genes associated with pregnancy complications.
Journal ArticleDOI
Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss
Weiqiang Chen,Suan-Sin Foo,Nestor E. Rulli,Adam Taylor,Kuo-Ching Sheng,Lara J. Herrero,Belinda L. Herring,Brett A. Lidbury,Rachel W. Li,Nicole C. Walsh,Nicole C. Walsh,Natalie A. Sims,Natalie A. Sims,Paul N. Smith,Suresh Mahalingam +14 more
TL;DR: It is shown that primary human osteoblasts (hOBs) can be productively infected by RRV, and that OBs are capable of producing proinflammatory mediators during alphavirus-induced arthralgia.