Waichi Wong

TL;DR: Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen, and it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation.

TL;DR: Although the observations support the utilization of ECD and DCD kidneys, these transplants are associated with increased costs and resource utilization and revised reimbursement guidelines will be required for centers that utilize these organs.

TL;DR: The analysis supports clonal deletion as a mechanism of allograft tolerance in CKBMT patients and validates the contribution of donor-reactive T cell clones identified before transplant by the method, supporting further exploration as a potential biomarker of transplant outcomes.

TL;DR: Post‐transplant circulating anti‐human leukocyte antigens (HLA)‐antibodies and C4d in allograft biopsies may be important in chronic rejection in renal transplant recipients (RTR) and anti‐HLA antibodies were significantly associated with pretransplant sensitization, acute rejection and in multivariate analysis, higher serum creatinine.

TL;DR: The breadth of autoantibody responses, together with the absence of consensual targets, suggests that these antibody responses result from systemic B-cell deregulation.