N
Nelson Goes
Researcher at Harvard University
Publications - 27
Citations - 3186
Nelson Goes is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & MHC class I. The author has an hindex of 17, co-authored 27 publications receiving 3016 citations. Previous affiliations of Nelson Goes include University of Alberta.
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Journal ArticleDOI
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Tatsuo Kawai,A. Benedict Cosimi,Thomas R. Spitzer,Nina Tolkoff-Rubin,Manikkam Suthanthiran,Susan L. Saidman,Juanita Shaffer,Frederic I. Preffer,Ruchuang Ding,Vijay K. Sharma,Jay A. Fishman,Bimalangshu R. Dey,Dicken S.C. Ko,Martin Hertl,Nelson Goes,Waichi Wong,Winfred W. Williams,Robert B. Colvin,Megan Sykes,David H. Sachs +19 more
TL;DR: Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen, and it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation.
Journal ArticleDOI
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
Changli Wei,Shafic El Hindi,Jing Li,Alessia Fornoni,Nelson Goes,Junichiro Sageshima,Dony Maiguel,S. Ananth Karumanchi,Hui-Kim Yap,Moin A. Saleem,Qing-Yin Zhang,Boris Nikolic,Abanti Chaudhuri,Pirouz Daftarian,Eduardo Salido,Armando Torres,Moro O. Salifu,Minnie M. Sarwal,Franz Schaefer,Christian Morath,Vedat Schwenger,Martin Zeier,Vineet Gupta,David M. Roth,Maria Pia Rastaldi,George W. Burke,Phillip Ruiz,Jochen Reiser +27 more
TL;DR: It is reported that serum soluble urokinase receptor (suPAR) is elevated in two-thirds of subjects with primary FSGS, but not in people with other glomerular diseases, and that a higher concentration of suPAR before transplantation underlies an increased risk for recurrence of FSGS after transplantation.
Journal ArticleDOI
Ischemic acute tubular necrosis induces an extensive local cytokine response. Evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10.
TL;DR: The data indicate that ischemic injury, and possibly other forms of injury, triggers a complex circuit of proinflammatory cytokines that could be relevant to clinical renal transplants, where ATN is associated with poor graft outcome.
Journal ArticleDOI
The “injury response”: A concept linking nonspecific injury, acute rejection, and long-term transplant outcomes
Philip F. Halloran,J. Homik,Nelson Goes,Sing Leung Lui,Joan Urmson,V. Ramassar,Sandra Cockfield +6 more
Journal ArticleDOI
Outcome of Kidney Transplantation Using Expanded Criteria Donors and Donation After Cardiac Death Kidneys: Realities and Costs
Reza F. Saidi,Nahel Elias,Tatsuo Kawai,Martin Hertl,M L Farrell,Nelson Goes,Waichi Wong,Choli Hartono,Jay A. Fishman,Camille N. Kotton,Nina Tolkoff-Rubin,Francis L. Delmonico,Cosimi Ab,Dicken S.C. Ko +13 more
TL;DR: Although the observations support the utilization of ECD and DCD kidneys, these transplants are associated with increased costs and resource utilization and revised reimbursement guidelines will be required for centers that utilize these organs.