Wakana Ohashi

TL;DR: Based on the fluorescence microscopic observations of mouse macrophage RAW264.7 cells, it is found that various arginine-rich peptides have a translocation activity very similar to Tat-(48–60), and the results strongly suggested the possible existence of a common internalization mechanism ubiquitous to arkinine- rich peptides.

TL;DR: In the case of the Tat, FHV, and octaarginine peptides, N-terminal stearylation of the peptides increases the transfection efficiency by approximately 100 times to reach the same order of magnitude as that of LipofectAMINE, one of the most efficient commercially available transfections agents.

TL;DR: It is concluded that SLC39A14 facilitates GPCR-mediated cAMP-CREB signaling by suppressing the basal PDE activity, and that this is one mechanism for Zn's involvement in systemic growth processes.

TL;DR: It is shown that Zn suppresses T( h)17-mediated autoimmune diseases at lest in part by inhibiting the development of T(h)17 cells via attenuating STAT3 activation, which is a critical step for T(n)17 development.

TL;DR: This is the first biochemical characterization of the physiologically important protein ZIP13 and the demonstration of homo-dimerization for a mammalian ZIP zinc transporter family member.