K
Keigo Nishida
Researcher at Suzuka University of Medical Science
Publications - 60
Citations - 4301
Keigo Nishida is an academic researcher from Suzuka University of Medical Science. The author has contributed to research in topics: Degranulation & Signal transduction. The author has an hindex of 26, co-authored 58 publications receiving 3917 citations. Previous affiliations of Keigo Nishida include Osaka University.
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Journal ArticleDOI
Zinc is a novel intracellular second messenger
Satoru Yamasaki,Kumiko Sakata-Sogawa,Aiko Hasegawa,Tomoyuki Suzuki,Koki Kabu,Emi Sato,Tomohiro Kurosaki,Susumu Yamashita,Makio Tokunaga,Makio Tokunaga,Keigo Nishida,Toshio Hirano +11 more
TL;DR: The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling.
Journal ArticleDOI
Zinc homeostasis and signaling in health and diseases: Zinc signaling
TL;DR: This review addresses recent findings regarding Zn signaling and its role in physiological processes and pathogenesis and proposes that intracellular ZN signaling falls into two classes, early and late Zn signaled.
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Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses.
TL;DR: It is shown that the Ca2+-binding endoplasmic reticulum protein STIM1 is critical to mast cell function and is key in promoting theCa2+ influx that is essential for FcεRI-mediated mast cell activation and anaphylaxis.
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FcεRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane
Keigo Nishida,Satoru Yamasaki,Yukitaka Ito,Koki Kabu,Kotaro Hattori,Tohru Tezuka,Hirofumi Nishizumi,Daisuke Kitamura,Ryo Goitsuka,Raif S. Geha,Tadashi Yamamoto,Takeshi Yagi,Toshio Hirano +12 more
TL;DR: It is shown that FcɛRI stimulation triggers the formation of microtubules in a manner independent of calcium, and that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway.
Journal ArticleDOI
STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
Toshiyuki Fukada,Takuya Ohtani,Yuichi Yoshida,Takahiro Shirogane,Keigo Nishida,Koichi Nakajima,Masahiko Hibi,Toshio Hirano +7 more
TL;DR: An ‘orchestrating model’ for cytokine and growth factor action is proposed in which contradictory signals are orchestrated to produce a specific effect in a target cell.