T
Toshiaki Hosaka
Researcher at Tokyo University of Science
Publications - 33
Citations - 1336
Toshiaki Hosaka is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Gene & Enterococcus hirae. The author has an hindex of 14, co-authored 27 publications receiving 1042 citations. Previous affiliations of Toshiaki Hosaka include Centre for Life.
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Journal ArticleDOI
A three-dimensional movie of structural changes in bacteriorhodopsin
Eriko Nango,Antoine Royant,Antoine Royant,Minoru Kubo,Takanori Nakane,Cecilia Wickstrand,Tetsunari Kimura,Tomoyuki Tanaka,Kensuke Tono,Changyong Song,Rie Tanaka,Toshi Arima,Ayumi Yamashita,Jun Kobayashi,Toshiaki Hosaka,Eiichi Mizohata,Przemyslaw Nogly,Michihiro Sugahara,Daewoong Nam,Takashi Nomura,Tatsuro Shimamura,Dohyun Im,Takaaki Fujiwara,Yasuaki Yamanaka,Byeonghyun Jeon,Tomohiro Nishizawa,Tomohiro Nishizawa,Kazumasa Oda,Masahiro Fukuda,Rebecka Andersson,Petra Båth,Robert Dods,Jan Davidsson,Shigeru Matsuoka,Satoshi Kawatake,Michio Murata,Osamu Nureki,Shigeki Owada,Takashi Kameshima,Takaki Hatsui,Yasumasa Joti,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Makina Yabashi,Ana-Nicoleta Bondar,Jörg Standfuss,Richard Neutze,So Iwata +47 more
TL;DR: Time-resolved serial femtosecond crystallography at an x-ray free electron laser shows how motions are choreographed as bR transports protons uphill against a transmembrane concentration gradient.
Journal ArticleDOI
Crystal structures of the human adiponectin receptors
Hiroaki Tanabe,Yoshifumi Fujii,Miki Okada-Iwabu,Masato Iwabu,Masato Iwabu,Yoshihiro Nakamura,Toshiaki Hosaka,Kanna Motoyama,Mariko Ikeda,Motoaki Wakiyama,Takaho Terada,Noboru Ohsawa,Masakatsu Hato,Satoshi Ogasawara,Tomoya Hino,Takeshi Murata,So Iwata,Kunio Hirata,Yoshiaki Kawano,Masaki Yamamoto,Tomomi Kimura-Someya,Mikako Shirouzu,Toshimasa Yamauchi,Takashi Kadowaki,Shigeyuki Yokoyama +24 more
TL;DR: In this article, the crystal structures of human AdipoR1 and AdipOR2 were reported at 2.9 and 2.4 A resolution, respectively, which represent a novel class of receptor structure.
Journal ArticleDOI
Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome.
Bum-Ho Bin,Bum-Ho Bin,Toshiyuki Fukada,Toshiaki Hosaka,Satoru Yamasaki,Wakana Ohashi,Shintaro Hojyo,Tomohiro Miyai,Keigo Nishida,Shigeyuki Yokoyama,Toshio Hirano +10 more
TL;DR: This is the first biochemical characterization of the physiologically important protein ZIP13 and the demonstration of homo-dimerization for a mammalian ZIP zinc transporter family member.
Crystal structures of the human adiponectin receptors
Hiroaki Tanabe,Yoshifumi Fujii,Miki Iwabu-Okada,Masato Iwabu,Yoshihiro Nakamura,Toshiaki Hosaka,Kanna Motoyama,Mariko Ikeda,Motoaki Wakiyama,Takaho Terada,Noboru Ohsawa,Masakatsu Hato,Satoshi Ogasawara,Tomoya Hino,Takeshi Murata,So Iwata,Kunio Hirata,Yoshiaki Kawano,Masaki Yamamoto,Tomomi Someya,Mikako Shirouzu,Toshimasa Yamauchi,Takashi Kadoaki,Shigeyuki Yokoyama +23 more
TL;DR: The present information will facilitate the understanding of novel structure–function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes.
Journal ArticleDOI
A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators.
David M. Needham,Susumu Yoshizawa,Toshiaki Hosaka,Camille Poirier,Camille Poirier,Chang Jae Choi,Chang Jae Choi,Elisabeth Hehenberger,Elisabeth Hehenberger,Nicholas A.T. Irwin,Susanne Wilken,Cheuk Man Yung,Cheuk Man Yung,Charles Bachy,Rika Kurihara,Yu Nakajima,Keiichi Kojima,Tomomi Kimura-Someya,Guy Leonard,Rex R. Malmstrom,Daniel R. Mende,Daniel K. Olson,Yuki Sudo,Sebastian Sudek,Thomas A. Richards,Edward F. DeLong,Patrick J. Keeling,Alyson E. Santoro,Mikako Shirouzu,Wataru Iwasaki,Alexandra Z. Worden,Alexandra Z. Worden +31 more
TL;DR: It is demonstrated that the rhodopsin shared by ChoanoViruses and PgV binds retinal and pumps protons when illuminated, indicating that light-dependent energy transfer systems are likely common components of giant viruses of photosynthetic and phagotrophic marine eukaryotes.