W
Wako Urano
Publications - 24
Citations - 1253
Wako Urano is an academic researcher. The author has contributed to research in topics: Arthritis & Gout. The author has an hindex of 14, co-authored 24 publications receiving 1197 citations.
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Journal ArticleDOI
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
Wako Urano,Atsuo Taniguchi,Hisashi Yamanaka,Eiichi Tanaka,Hiroshi Nakajima,Yuko Matsuda,Hideto Akama,Yutaka Kitamura,Naoyuki Kamatani +8 more
TL;DR: Both single locus and haplotype analyses suggest that polymorphisms within the MTHFR gene are associated with both the efficacy and toxicity of MTX in rheumatoid arthritis patients.
Journal ArticleDOI
Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis
Yuko Matsuda,Gurkirpal Singh,Hisashi Yamanaka,Eiichi Tanaka,Wako Urano,Atsuo Taniguchi,Terunobu Saito,Masako Hara,Taisuke Tomatsu,Naoyuki Kamatani +9 more
TL;DR: The final version of the J-HAQ is a valid and reliable instrument for measuring functional status in Japanese-speaking RA patients and shows excellent internal reliability.
Journal Article
The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis
Wako Urano,Hisashi Yamanaka,Hiroshi Tsutani,Hiroshi Nakajima,Yuko Matsuda,Atsuo Taniguchi,Masako Hara,Naoyuki Kamatani +7 more
TL;DR: Decrease in SUA during acute gouty arthritis is associated with increased urinary excretion of uric acid; an inflammatory process may play a role in the mechanism.
Journal ArticleDOI
Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate
Promsuk Jutabha,Naohiko Anzai,Kenichiro Kitamura,Atsuo Taniguchi,Shuji Kaneko,Kunimasa Yan,Hideomi Yamada,Hidetaka Shimada,Toru Kimura,Tomohisa Katada,Toshiyuki Fukutomi,Kimio Tomita,Wako Urano,Hisashi Yamanaka,George Seki,Toshiro Fujita,Yoshinori Moriyama,Akira Yamada,Shunya Uchida,Michael F. Wempe,Hitoshi Endou,Hiroyuki Sakurai +21 more
TL;DR: It is demonstrated that an orphan transporter hNPT4 (human sodium phosphate transporter 4; SLC17A3) was a multispecific organic anion efflux transporter expressed in the kidneys and liver and functioned as a voltage-driven urate transporter.
Journal ArticleDOI
Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice.
Atsuo Taniguchi,Wako Urano,Eiichi Tanaka,Shiori Furihata,Shigeo Kamitsuji,Eisuke Inoue,Mariko Yamanaka,Hisashi Yamanaka,Naoyuki Kamatani +8 more
TL;DR: Three retrospective studies on the associations between genomic variations and adverse events or efficacy of two different disease-modifying antirheumatic drugs were replicated and the usefulness of the tests is worth being tested in clinical practice.