W
Walter Manucha
Researcher at National University of Cuyo
Publications - 122
Citations - 2299
Walter Manucha is an academic researcher from National University of Cuyo. The author has contributed to research in topics: Medicine & Oxidative stress. The author has an hindex of 23, co-authored 102 publications receiving 1648 citations. Previous affiliations of Walter Manucha include Facultad de Ciencias Médicas & National Scientific and Technical Research Council.
Papers
More filters
Journal ArticleDOI
Role of Mitochondrial Dysfunction in Hypertension and Obesity.
Vicente Lahera,Natalia de las Heras,Antonio J. López-Farré,Walter Manucha,Walter Manucha,León Ferder +5 more
TL;DR: Modifications of mitochondrial dynamics in organs involved in energy metabolism such as the pancreas, liver, skeletal muscle, and white adipose tissue could be of relevance for the development of insulin resistance, obesity, and type 2 diabetes.
Journal ArticleDOI
The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
TL;DR: There may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors.
Journal ArticleDOI
Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment.
Virna Margarita Martín Giménez,Felipe Inserra,Carlos D. Tajer,Javier Mariani,León Ferder,Russel J. Reiter,Walter Manucha,Walter Manucha +7 more
TL;DR: The renin-angiotensin system exaltation with consequent inflammatory response has a leading role in the physiopathology of COVID-19 infection; and it may be down-regulated by vitamin D and melatonin in many organs, so it is also essential to analyze this potential therapeutic association and their relation with RAS as part of this new approach.
Journal ArticleDOI
Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance.
TL;DR: Elucidating the IR signaling pathways and the roles of NO and HSPs is relevant to the application of new treatments, such as heat shock and thermal therapy, nitrosylated drugs, chemical chaperones or exercise training.
Journal ArticleDOI
Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D.
Natalia de las Heras,Virna Margarita Martín Giménez,León Ferder,Walter Manucha,Vicente Lahera +4 more
TL;DR: The purpose of this review is to deepen the knowledge about the role of mitochondria and vitamin D directly involved in the regulation of oxidative stress and the inflammatory state in SARS-CoV-2 infection.