S
Sudha W. Mitra
Researcher at Merck & Co.
Publications - 17
Citations - 3050
Sudha W. Mitra is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Somatostatin receptor 2. The author has an hindex of 15, co-authored 17 publications receiving 2966 citations. Previous affiliations of Sudha W. Mitra include Massachusetts Institute of Technology.
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Journal ArticleDOI
Immunolocalization of estrogen receptor β in the mouse brain: Comparison with estrogen receptor α
Sudha W. Mitra,Elena Hoskin,Joel B. Yudkovitz,Lisset Pear,Hilary A. Wilkinson,Shinji Hayashi,Donald W. Pfaff,Sonoko Ogawa,Susan P. Rohrer,James M. Schaeffer,Bruce S. McEwen,Stephen E. Alves +11 more
TL;DR: The development of an ERβ-selective antibody that cross-reacts with mouse, rat, and human ERβ protein and its use to determine the distribution of ERβ in the murine brain is reported.
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A detailed model of reverse transcription and tests of crucial aspects.
TL;DR: A model of reverse transcription has been devised by which the detailed architecture of ten molecular structures is predicted, and it appears to provide a credible description ofreverse transcription.
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Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry
Susan P. Rohrer,Elizabeth T. Birzin,Ralph T. Mosley,Scott C. Berk,Steven M. Hutchins,Dong-Ming Shen,Yusheng Xiong,Edward C. Hayes,Rupa M. Parmar,Forrest Foor,Sudha W. Mitra,Sylvia J. Degrado,Min Shu,John M. Klopp,Sheng-Jian Cai,Allan D. Blake,Wanda W.-S. Chan,Alex Pasternak,Lihu Yang,Arthur A. Patchett,Roy G. Smith,Kevin T. Chapman,James M. Schaeffer +22 more
TL;DR: The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions, including inhibition of glucagon release from mouse pancreatic alpha cells and mediator of insulin secretion from pancreatic beta cells.
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Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration.
Charles B. Shoemaker,Stephen P. Goff,Eli Gilboa,Michael Paskind,Sudha W. Mitra,David Baltimore +5 more
TL;DR: Closed circular Moloney murine leukemia virus (M-MuLV) DNA was prepared from recently infected cells and cloned in a lambda vector, providing explicit information concerning the mechanism by which retrovirus DNA integrates into host cell DNA.
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Nuclear Receptors Have Distinct Affinities for Coactivators: Characterization by Fluorescence Resonance Energy Transfer
Gaochao Zhou,Richard D. Cummings,Ying Li,Sudha W. Mitra,Hilary A. Wilkinson,Alex Elbrecht,Jeffrey D. Hermes,James M. Schaeffer,Roy G. Smith,David E. Moller +9 more
TL;DR: FRET-based coactivator association is a novel approach for characterizing nuclear receptor agonists or antagonists; individual ligands display potencies that are predictive of in vivo effects and distinct profiles of maximal activity that are suggestive of alternative receptor conformations.