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Wannian Zhang
Researcher at Second Military Medical University
Publications - 171
Citations - 5576
Wannian Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Camptothecin & Candida albicans. The author has an hindex of 35, co-authored 166 publications receiving 4310 citations. Previous affiliations of Wannian Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
Chalcone: A Privileged Structure in Medicinal Chemistry.
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
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A Three-Dimensional Model of Lanosterol 14α-Demethylase of Candida albicans and Its Interaction with Azole Antifungals
TL;DR: The structurally and functionally important residues such as the heme binding residues, the residues interacting with redox-partner protein and/or involved in electron transfer, the residue lining substrate access channel, and the substrate binding residues were identified from the model and are candidates for further site-directed mutagenesis and site-specific antipeptide antibody binding experiments.
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Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking
Chunquan Sheng,Wannian Zhang,Haitao Ji,Min Zhang,Yunlong Song,Hui Xu,Jie Zhu,Zhenyuan Miao,Qingfen Jiang,Jianzhong Yao,Youjun Zhou,Ju Zhu,Jiaguo Lü +12 more
TL;DR: In vitro antIFungal assay revealed that the antifungal activities of these novel azoles were greatly improved, which confirmed the reliability of the model from molecular modeling.
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New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.
Guoqiang Dong,Shengzheng Wang,Zhenyuan Miao,Jianzhong Yao,Yongqiang Zhang,Zizhao Guo,Wannian Zhang,Chunquan Sheng +7 more
TL;DR: A library of novel evodiamine derivatives bearing various substitutions or modified scaffold were synthesized and showed substantial increase of the antitumor activity, with GI(50) values lower than 3 nM.
Journal ArticleDOI
Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.
Shengzheng Wang,Shengzheng Wang,Kun Fang,Guoqiang Dong,Shuqiang Chen,Na Liu,Zhenyuan Miao,Jianzhong Yao,Jian Li,Wannian Zhang,Chunquan Sheng +10 more
TL;DR: Antitumor mechanism and target profiling studies indicate that compound 66c is the first-in-class triple topoisomerase I/topoisomersase II/tubulin inhibitor.