W
Wannian Zhang
Researcher at Second Military Medical University
Publications - 171
Citations - 5576
Wannian Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Camptothecin & Candida albicans. The author has an hindex of 35, co-authored 166 publications receiving 4310 citations. Previous affiliations of Wannian Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures
Yongqiang Zhang,Shanchao Wu,Shengzheng Wang,Kun Fang,Kun Fang,Guoqiang Dong,Na Liu,Zhenyuan Miao,Jianzhong Yao,Jian Li,Wannian Zhang,Sheng Chunquan,Sheng Chunquan,Wei Wang,Wei Wang +14 more
TL;DR: A powerful divergent cascade strategy has been explored for the easy construction of diverse enantioenriched pyrazole-derived scaffolds from readily available chiral fused pyrazoles-tetrahydropyran acetals, revealing potent anticancer lead compounds that deserve further development.
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Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.
Jiang Zhigan,Julin Gu,Chen Wang,Shengzheng Wang,Na Liu,Yan Jiang,Guoqiang Dong,Yan Wang,Yang Liu,Jianzhong Yao,Zhenyuan Miao,Wannian Zhang,Chunquan Sheng +12 more
TL;DR: A series of novel antifungal triazoles with substituted triazole-piperidine side chains were designed and synthesized and showed good inhibitory activity against a variety of clinically important fungal pathogens.
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Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.
Shipeng He,Guoqiang Dong,Zhibin Wang,Wei Chen,Yahui Huang,Li Zhengang,Yan Jiang,Na Liu,Jianzhong Yao,Zhenyuan Miao,Wannian Zhang,Sheng Chunquan +11 more
TL;DR: A series of hybrid molecules designed and synthesized on the basis of 3-amino-10-hydroxylevodiamine and SAHA proved to be a potent inhibitor of topoisomerase I/II and HDAC with good antiproliferative and apoptotic activities.
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Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
TL;DR: This review summarizes the recent advances in the medicinal chemistry of small-molecule inhibitors in the areas of drug design, structure-activity relationships, and biological and biochemical properties and concludes that further research is required for the discovery of more potent inhibitors.
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Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease.
TL;DR: The role of NRF2 in AD and theNRF2 activators advanced into clinical and preclinical studies will be summarzied.