W
Wannian Zhang
Researcher at Second Military Medical University
Publications - 171
Citations - 5576
Wannian Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Camptothecin & Candida albicans. The author has an hindex of 35, co-authored 166 publications receiving 4310 citations. Previous affiliations of Wannian Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers
Jianzhong Yao,Wannian Zhang,Chunquan Sheng,Zhenyuan Miao,Feng Yang,Jianxin Yu,Ling Zhang,Yunlong Song,Ting Zhou,Youjun Zhou +9 more
TL;DR: Among them, BCPDs 16 and 18 are more effective and promising PDT photosensitizers based on the studies with BEL-7402 cells and show nearly the same photodynamic efficacy as BPDMA.
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Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury
Le Zhang,Xu Lijuan,Haihu Chen,Wannian Zhang,Chengguo Xing,Qu Zhuo,Jian-Qiang Yu,Chunlin Zhuang +7 more
TL;DR: In this article, a series of isothiocyanate-containing naphthalensulfonamides with the thioether, sulfoxide and sulfone moieties were designed by a structure-based molecular hybridization strategy using NXPZ-2 and the Nrf2 activator sulforaphane.
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Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.
Wenfeng Liu,Lingjian Zhu,Wei Guo,Chunlin Zhuang,Yongqiang Zhang,Chunquan Sheng,Pengfei Cheng,Jianzhong Yao,Wenya Wang,Guoqiang Dong,Shengzheng Wang,Zhenyuan Miao,Wannian Zhang +12 more
TL;DR: A series of novel 7-acyl derivatives of homocamptothecin (hCPT) were designed and synthesized with the purpose to improve antitumor activity of hCPT, via Minisci free-radical reaction from 10-methoxyhomocamPTothecin.
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Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents.
TL;DR: Together, entecavir and imipenem might be candidates for the treatment of CSS and inhibited the release of TNF-α and IL-10 in human peripheral blood mononuclear cells (hPBMCs).
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In vivo pharmacokinetics and in vitro antifungal activity of iodiconazole, a new triazole, determined by microdialysis sampling
TL;DR: It was demonstrated that well-calibrated microdialysis sampling in rats could be used to assess the percutaneous penetration kinetics of iodiconazole cream and showed a reservoir effect in the skin following topical application.