W
Wannian Zhang
Researcher at Second Military Medical University
Publications - 171
Citations - 5576
Wannian Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Camptothecin & Candida albicans. The author has an hindex of 35, co-authored 166 publications receiving 4310 citations. Previous affiliations of Wannian Zhang include Chinese Ministry of Education.
Papers
More filters
Journal ArticleDOI
N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure-Activity Relationships, and in Vivo Efficacy.
Hao Zhang,Xu Lijuan,Xia Qin,Xiaofei Chen,Hui Cong,Longmiao Hu,Long Chen,Zhenyuan Miao,Wannian Zhang,Zhenyu Cai,Zhenyu Cai,Chunlin Zhuang,Chunlin Zhuang +12 more
TL;DR: Three rounds of structural optimizations of TAK-632 were performed and structure-activity relationships were elucidated to generate more potent inhibitors by targeting RIPK3, and analogues with carbamide groups exhibited great antinecroptotic activities and compound 42 showed >60-fold selectivity for RIPK2 than RIPK1.
Journal ArticleDOI
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Ning Meng,Hua Tang,Hao Zhang,Cheng-Shi Jiang,Li Su,Xiao Min,Wannian Zhang,Hua Zhang,Zhenyuan Miao,Wen Zhang,Chunlin Zhuang +10 more
TL;DR: A series of novel hydronaphthoquinones can be used as promising lead compounds for the study of Keap1‐Nrf2 protein‐protein interactions and further anti‐myocarditis drug development.
Journal ArticleDOI
Chemical Composition and Antidiabetic Activity of Opuntia Milpa Alta Extracts
TL;DR: The results indicate that the petroleum ether extract is the major hypoglycemic part in edible Opuntia Milpa Alta, which may be developed to a potential natural Hypoglycemic functional ingredient.
Journal ArticleDOI
Novel conformationally restricted triazole derivatives with potent antifungal activity
Wenya Wang,Shengzheng Wang,Yang Liu,Guoqiang Dong,Yong-Bing Cao,Zhenyuan Miao,Jianzhong Yao,Wannian Zhang,Chunquan Sheng +8 more
TL;DR: A series of new conformationally restricted triazole derivatives possessing benzylpiperidin-4-yl methyl amino side chains were designed and synthesized and showed moderate to excellent in vitro antifungal activity against most of the tested pathogenic fungi.
Journal ArticleDOI
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy
TL;DR: This compound showed highly potent activity against cell necroptosis and systemic inflammatory response syndrome and was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of UC.