W
Wannian Zhang
Researcher at Second Military Medical University
Publications - 171
Citations - 5576
Wannian Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Camptothecin & Candida albicans. The author has an hindex of 35, co-authored 166 publications receiving 4310 citations. Previous affiliations of Wannian Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
New triazole derivatives containing substituted 1,2,3-triazole side chains: Design, synthesis and antifungal activity
Hai-Jiang Chen,Hai-Jiang Chen,Yanjuan Jiang,Yanjuan Jiang,Yong-Qiang Zhang,Qi-Wei Jing,Na Liu,Yan Wang,Wannian Zhang,Chunquan Sheng,Chunquan Sheng +10 more
TL;DR: Compound 7l was highly active against Candida albicans and Candida glabrata and showed potent in vivo antifungal efficacy in the Caenorhabditis elegans – C.Albicans infection model.
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Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents.
Qingyan Sun,Wannian Zhang,Jian-Ming Xu,Yong-Bing Cao,Qiuye Wu,Dazhi Zhang,Chao-Mei Liu,Shichong Yu,Yuan-Ying Jiang +8 more
TL;DR: Results of preliminary antifungal tests against six human pathogenic fungi in vitro showed that all title compounds exhibited activity against fungi tested to some extent except against C. tropicalis.
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Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells
Youjun Zhang,Hao Ma,Yuelin Wu,Zhongli Wu,Zhengguang Yao,Wannian Zhang,Chunlin Zhuang,Zhenyuan Miao +7 more
TL;DR: Twelve analogues have been designed and synthesized with non-substituted benzyl rings or heterocycles in this work and most of the compounds showed better anticancer activities than the parent PL without apparent toxicity in normal cells.
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Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
Shengzheng Wang,Gang Jin,Wenya Wang,Lingjian Zhu,Yongqiang Zhang,Guoqiang Dong,Yang Liu,Chunlin Zhuang,Zhenyuan Miao,Jianzhong Yao,Wannian Zhang,Chunquan Sheng +11 more
TL;DR: The SAR results were supported by molecular docking and the N-substitutions were found to be important for the conformation of the side chains and the binding mode of the azoles are useful for further lead optimization.
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Structure-based bioisosterism design of thio-benzoxazepinones as novel necroptosis inhibitors.
TL;DR: In this article, the bioisosterism strategy was applied to replace the amide and benzene ring of GSK′772 based on the co-crystal structure with its binding target RIPK1.