Wannian Zhang

TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.

TL;DR: The structurally and functionally important residues such as the heme binding residues, the residues interacting with redox-partner protein and/or involved in electron transfer, the residue lining substrate access channel, and the substrate binding residues were identified from the model and are candidates for further site-directed mutagenesis and site-specific antipeptide antibody binding experiments.

TL;DR: In vitro antIFungal assay revealed that the antifungal activities of these novel azoles were greatly improved, which confirmed the reliability of the model from molecular modeling.

TL;DR: A library of novel evodiamine derivatives bearing various substitutions or modified scaffold were synthesized and showed substantial increase of the antitumor activity, with GI(50) values lower than 3 nM.

TL;DR: Antitumor mechanism and target profiling studies indicate that compound 66c is the first-in-class triple topoisomerase I/topoisomersase II/tubulin inhibitor.