Wassim Y. Almawi

TL;DR: The current state of knowledge of the mechanism of action of GCS is summarized, including the phenomenon of steroid‐induced rebound, which ensues upon GCS withdrawal, which is summarized in this review.

TL;DR: It should be noted that, in exerting its effect, activated GR did not affect the correct assembly of the pre-initiation (DAB) complex, but acted rather more proximally in inhibiting the correctAssembly of transcription factors in the promoter region, and thus transcriptional initiation.

TL;DR: Glucocorticoids exert their anti‐inflammatory and immunosuppressive effects by inhibiting the expression of cytokines andhesion molecules through their capacity to diffuse through the cell membrane and bind their cytosolic GC receptor, which subsequently undergoes nuclear translocation and modulates transcriptional activation through association with promoter elements, GC response elements (GRE).

TL;DR: It is demonstrated that antiproliferative concentrations of dexamethasone and 6 alpha-methylprednisolone block mitogen-induced IL-2 gene expression in human peripheral blood mononuclear leukocytes in a concentration-dependent fashion.

TL;DR: In this large pooled analysis of case–control and cohort studies investigating in adults the association between each variant and VTE, no effect was found for C677T MTHFR on VTE; FVL and PT20210A were confirmed to be moderate risk factors.