J
Jeppe Zacho
Researcher at Copenhagen University Hospital
Publications - 21
Citations - 3241
Jeppe Zacho is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Population & Odds ratio. The author has an hindex of 17, co-authored 21 publications receiving 2923 citations. Previous affiliations of Jeppe Zacho include University of Copenhagen & Herlev Hospital.
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Journal ArticleDOI
Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease
Jeppe Zacho,Anne Tybjærg-Hansen,Jan Skov Jensen,Peer Grande,Henrik Sillesen,Børge G. Nordestgaard +5 more
TL;DR: Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease, but these polymorphisms are not in themselves associated with an increased risk ofIschemicascular disease.
Journal ArticleDOI
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
G. Eiriksdottir,T. B. Harris,L. J. Launer,Vilmundur Gudnason,Aaron R. Folsom,Gavin Andrews,C. M. Ballantyne,Nilesh J. Samani,A. S. Hall,P. S. Braund,A. J. Balmforth,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,Gordon D.O. Lowe,Nicholas J. Timpson,Shah Ebrahim,Yoav Ben-Shlomo,George Davey-Smith,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Jeppe Zacho,Matthew A. Brown,Manjinder S. Sandhu,Sally L. Ricketts,Sofie Ashford,Leslie A. Lange,Alexander P. Reiner,Mary Cushman,Russel Tracy,C. Wu,J. Ge,Y. Zou,A. Sun,Joseph Hung,Brendan McQuillan,Peter L. Thompson,John Beilby,Nicole M. Warrington,Lyle J. Palmer,Christoph Wanner,Christiane Drechsler,Michael Hoffmann,F. G. R. Fowkes,Ioanna Tzoulaki,Meena Kumari,Michelle A. Miller,Michael Marmot,Charlotte Onland-Moret,Y. T. van der Schouw,J.M.A. Boer,Cisca Wijmenga,Kay-Tee Khaw,Ramachandran S. Vasan,Renate B. Schnabel,J. F. Yamamoto,E J Benjamin,Heribert Schunkert,Jeanette Erdmann,Inke R. König,Christian Hengstenberg,Benedetta D. Chiodini,MariaGrazia Franzosi,Silvia Pietri,Francesca Gori,Megan E. Rudock,Yongmei Liu,Kurt Lohman,Steve E. Humphries,Anders Hamsten,Paul Norman,Graeme J. Hankey,Konrad Jamrozik,Eric B. Rimm,J. K. Pai,Bruce M. Psaty,Susan R. Heckbert,J. C. Bis,Salim Yusuf,Sonia S. Anand,Engert Jc,C. Xie,Ryan L. Collins,Robert Clarke,David L.H. Bennett,Jaspal S. Kooner,John C. Chambers,Paul Elliott,W. März,Marcus E. Kleber,Bernhard O. Böhm,Winkelmann Br,Olle Melander,Göran Berglund,Wolfgang Koenig,Barbara Thorand,Jens Baumert,Annette Peters,JoAnn E. Manson,J.A. Cooper,P.J. Talmud,Per Ladenvall,Lovisa Johansson,J. H. Jansson,Göran Hallmans,Muredach P. Reilly,Liming Qu,Man Li,Daniel J. Rader,Hugh Watkins,Jemma C. Hopewell,Danish Saleheen,John Danesh,Philippe M. Frossard,Naveed Sattar,Michele Robertson,J. Shepherd,Ernst J. Schaefer,A. Hofman,J. C. M. Witteman,Isabella Kardys,Abbas Dehghan,U de Faire,Anna M. Bennet,Bruna Gigante,Karin Leander,Bas J M Peters,A.H. Maitland-van der Zee,A.H. De Boer,Olaf H. Klungel,Philip Greenland,J. Dai,Simin Liu,Eric J. Brunner,Mika Kivimäki,Denis St. J. O’Reilly,Ian Ford,Chris J. Packard +137 more
TL;DR: Human genetic data indicate that C reactive protein concentration itself is unlikely to be even a modest causal factor in coronary heart disease.
Journal ArticleDOI
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.
Michael V. Holmes,Paul J. Newcombe,Paul J. Newcombe,Jaroslav A. Hubacek,Reecha Sofat,Sally L. Ricketts,Jackie A. Cooper,Monique M.B. Breteler,Leonelo E. Bautista,Pankaj Sharma,John C. Whittaker,John C. Whittaker,Liam Smeeth,F. Gerald R. Fowkes,Ale Algra,Ale Algra,Veronika M. Shmeleva,Zoltan Szolnoki,Mark Roest,Michael Linnebank,Jeppe Zacho,Mike A. Nalls,Andrew B. Singleton,Luigi Ferrucci,John Hardy,Bradford B. Worrall,Stephen S. Rich,Mar Matarin,Paul Norman,Leon Flicker,Osvaldo P. Almeida,Frank M. van Bockxmeer,Hiroshi Shimokata,Kay-Tee Khaw,Nicholas J. Wareham,Martin Bobak,Jonathan A C Sterne,George Davey Smith,Philippa J. Talmud,Cornelia M. van Duijn,Steve E. Humphries,Jackie F. Price,Shah Ebrahim,Debbie A Lawlor,Graeme J. Hankey,James F. Meschia,Manjinder S. Sandhu,Aroon D. Hingorani,Juan P. Casas,Juan P. Casas +49 more
TL;DR: In regions with increasing levels or established policies of population folate supplementation, evidence from genetic studies and randomised trials is concordant in suggesting an absence of benefit from lowering of homocysteine for prevention of stroke.
Journal ArticleDOI
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.
Nicholas J. Timpson,Børge G. Nordestgaard,Roger M. Harbord,Jeppe Zacho,Timothy M. Frayling,Anne Tybjærg-Hansen,G Davey Smith +6 more
TL;DR: The observed association between circulating CRP and measured BMI is likely to be driven by BMI, with CRP being a marker of elevated adiposity, suggesting the method of reciprocal randomization has general applicability within inter-correlated networks of metabolic components.
Journal ArticleDOI
The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach.
Børge G. Nordestgaard,Tom Palmer,Marianne Benn,Marianne Benn,Jeppe Zacho,Jeppe Zacho,Anne Tybjærg-Hansen,George Davey Smith,Nicholas J. Timpson +8 more
TL;DR: A Mendelian randomization analysis conducted by Børge G. Nordestgaard and colleagues using data from observational studies supports a causal relationship between body mass index and risk for ischemic heart disease.