Wei Chen

TL;DR: It is shown that AD pathology might not only affect brain function directly, but also exacerbate cognitive deficits through reducing the level of SCFAs via alterations of gut microbiota induced by intestinal amyloid deposition, suggesting a novel route for therapeutic intervention in AD.

TL;DR: In this paper, SARS-CoV-2 was found to cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of tight junctions (TJs).

TL;DR: The CRISPR/Cas9 system makes it possible to efficiently and reliably generate gene knock-out rats by co-injection of Cas9 mRNA and sgRNAs into fertilized eggs and observed the gene modifications are germline transmittable.

TL;DR: It is shown that both Scr7 and Cas9 protein can increase the precise modification, relatively lower compared with nonhomologous end-joining (NHEJ) pathway and extremely expected to be improved.

TL;DR: This model has rescued some deficiency of the existing rodent models, such as the transient hyperglycemia of db/db mice in the C57BL/6J genetic background and the delayed onset of glucose intolerance in the Zucker rats, and it is proven to be a useful animal model for biomedical and pharmacological research on obesity and diabetes.