Wei-Ping Yu

TL;DR: Experiments with transgenic mice show that platelet-derived growth factor (PDGF) drives progenitor cell division and suggest that slowing of and exit from the cycle reflects a decline in PDGF signaling.

TL;DR: Signals from the notochord/floor plate are necessary and sufficient to induce the development of ventrally derived oligodendroglia and appear to act by specifying the future fate(s) of neuroepithelial cells at the ventricular surface rather than by influencing the proliferation or differentiation of prespecified progenitor cells in the parenchyma of the cord.

TL;DR: The results support the idea that the ventricular zone is a mosaic of specialized progenitor cells and the hypothesis that the oligodendrocyte lineage originates at a discrete location in the ventral ventricular Zone of the embryonic day 14 rat spinal cord is supported.

TL;DR: It is found that mice with a targeted deletion in the Fgfr3 locus strongly upregulate Gfap in grey matter (protoplasmic) astrocytes, implying that signalling through F gfr3 normally represses GfAP expression in vivo.

TL;DR: A lineage diagram that connects oligodendrocytes and motor neurons is proposed and that takes into account the fact that motor neurons and oligodendedrocyte precursors are generated at different times during development.