Wei Qu

TL;DR: This minireview focused on direct evidence for the generation of free radicals in intact animals following acute Cd overload and discussed the association of ROS in chronic Cd toxicity and carcinogenesis.

TL;DR: Results indicate that, while cadmium is an effective inhibitor of DNA MeTase and initially induces DNA hypomethylation, prolonged exposure results in DNA hypermethylation and enhanced DNA Me tase activity.

TL;DR: Analysis of the effect of inorganic arsenic on Nrf2 expression and localization in HaCaT cells found that arsenic enhanced cellular expression of NRF2 at the transcriptional and protein levels and activated expression ofNrf2-related genes in these cells, and indicated that H(2)O(2), rather than *O( 2)(-), is the mediator of nuclear N RF2 accumulation.

TL;DR: PGHS-1 is the predominant enzyme that biosynthesizes PGE(2) in the normal mouse lung and products limit allergic lung inflammation and IgE secretion and promote normal lung function, and airway inflammation can be dissociated from the development of airway hyperresponsiveness in PGHS-2(-/-) mice.

TL;DR: The gene expression pattern in mice treated with inorganic arsenicals is profiled, which adds to the understanding of acute arsenic poisoning and toxicity.