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Wei Qu
Researcher at National Institutes of Health
Publications - 56
Citations - 4151
Wei Qu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Metallothionein & Arsenic toxicity. The author has an hindex of 33, co-authored 53 publications receiving 3861 citations. Previous affiliations of Wei Qu include Research Triangle Park.
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Journal ArticleDOI
Role of oxidative stress in cadmium toxicity and carcinogenesis.
Jie Liu,Wei Qu,Maria B. Kadiiska +2 more
TL;DR: This minireview focused on direct evidence for the generation of free radicals in intact animals following acute Cd overload and discussed the association of ROS in chronic Cd toxicity and carcinogenesis.
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Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
TL;DR: Results indicate that, while cadmium is an effective inhibitor of DNA MeTase and initially induces DNA hypomethylation, prolonged exposure results in DNA hypermethylation and enhanced DNA Me tase activity.
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Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
TL;DR: Analysis of the effect of inorganic arsenic on Nrf2 expression and localization in HaCaT cells found that arsenic enhanced cellular expression of NRF2 at the transcriptional and protein levels and activated expression ofNrf2-related genes in these cells, and indicated that H(2)O(2), rather than *O( 2)(-), is the mediator of nuclear N RF2 accumulation.
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Allergic lung responses are increased in prostaglandin H synthase–deficient mice
Stephen H. Gavett,Sharon L. Madison,Patricia C. Chulada,Paula E. Scarborough,Wei Qu,James E. Boyle,Howard F. Tiano,Christopher A. Lee,Robert Langenbach,Victor L. Roggli,Darryl C. Zeldin +10 more
TL;DR: PGHS-1 is the predominant enzyme that biosynthesizes PGE(2) in the normal mouse lung and products limit allergic lung inflammation and IgE secretion and promote normal lung function, and airway inflammation can be dissociated from the development of airway hyperresponsiveness in PGHS-2(-/-) mice.
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Stress-Related Gene Expression in Mice Treated with Inorganic Arsenicals
TL;DR: The gene expression pattern in mice treated with inorganic arsenicals is profiled, which adds to the understanding of acute arsenic poisoning and toxicity.