Wei Tong

TL;DR: Four somatic gain-of-function mutations affecting JAK2 exon 12 define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis.

TL;DR: The elements required to generate myeloid- and trophoblast-specific transgenes as well as a model system for the study of mononuclear phagocyte development and function are defined.

TL;DR: It is shown that the HSC-supportive mouse fetal liver CD3+ cells specifically express the proteins angiopoietin-like 2 and Angptl3, which are capable of stimulating expansion of hematopoietic stem cells in culture.

TL;DR: Coexpression of the JAK2V617F mutant kinase with a homodimeric Type I cytokine receptor, the erythropoietin receptor (EpoR), the thrombopoetin receptor, or the granulocyte colony-stimulating-factor receptor, is necessary for transformation of hematopoietic cells to growth-factor independence and for hormone-independent activation of JAK-STAT signaling.

TL;DR: A novel miRNA-regulated pathway that protects erythrocytes against oxidant stress is defined and how a miRNA can influence gene expression by altering the activity of a key transcription factor is illustrated.