M
Mitchell J. Weiss
Researcher at St. Jude Children's Research Hospital
Publications - 263
Citations - 23376
Mitchell J. Weiss is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Haematopoiesis & Gene. The author has an hindex of 74, co-authored 241 publications receiving 20575 citations. Previous affiliations of Mitchell J. Weiss include Children's Hospital of Philadelphia & University of Pennsylvania.
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Journal ArticleDOI
An early haematopoietic defect in mice lacking the transcription factor GATA-2.
Fong-Ying Tsai,Fong-Ying Tsai,Gordon Keller,Frank C. Kuo,Mitchell J. Weiss,Jianzhou Chen,Margery Rosenblatt,Frederick W. Alt,Stuart H. Orkin,Stuart H. Orkin +9 more
TL;DR: It is demonstrated that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type, and proposed that it regulates genes controlling growth factor responsiveness or the proliferative capacity of early haem atopoietic cells.
Journal ArticleDOI
A comparative encyclopedia of DNA elements in the mouse genome
Feng Yue,Feng Yue,Yong Cheng,Alessandra Breschi,Jeff Vierstra,Weisheng Wu,Weisheng Wu,Tyrone Ryba,Tyrone Ryba,Richard Sandstrom,Zhihai Ma,Carrie A. Davis,Benjamin D. Pope,Yin Shen,Dmitri D. Pervouchine,Sarah Djebali,Robert E. Thurman,Rajinder Kaul,Eric Rynes,Anthony Kirilusha,Georgi K. Marinov,Brian A. Williams,Diane Trout,Henry Amrhein,Katherine I. Fisher-Aylor,Igor Antoshechkin,Gilberto DeSalvo,Lei Hoon See,Meagan Fastuca,Jorg Drenkow,Chris Zaleski,Alexander Dobin,Pablo Prieto,Julien Lagarde,Giovanni Bussotti,Andrea Tanzer,Olgert Denas,Kanwei Li,M. A. Bender,M. A. Bender,Miaohua Zhang,Rachel Byron,Mark Groudine,Mark Groudine,David McCleary,Long Pham,Zhen Ye,Samantha Kuan,Lee Edsall,Yi-Chieh Wu,Matthew D. Rasmussen,Mukul S. Bansal,Manolis Kellis,Manolis Kellis,Cheryl A. Keller,Christapher S. Morrissey,Tejaswini Mishra,Deepti Jain,Nergiz Dogan,Robert S. Harris,Philip Cayting,Trupti Kawli,Alan P. Boyle,Alan P. Boyle,Ghia Euskirchen,Anshul Kundaje,Shin Lin,Yiing Lin,Camden Jansen,Venkat S. Malladi,Melissa S. Cline,Drew T. Erickson,Vanessa M. Kirkup,Katrina Learned,Cricket A. Sloan,Kate R. Rosenbloom,Beatriz Lacerda de Sousa,Kathryn Beal,Miguel Pignatelli,Paul Flicek,Jin Lian,Tamer Kahveci,Dongwon Lee,W. James Kent,Miguel Santos,Javier Herrero,Cedric Notredame,Audra K. Johnson,Shinny Vong,Kristen Lee,Daniel Bates,Fidencio Neri,Morgan Diegel,Theresa K. Canfield,Peter J. Sabo,Matthew S. Wilken,Thomas A. Reh,Erika Giste,Anthony Shafer,Tanya Kutyavin,Eric Haugen,Douglas Dunn,Alex Reynolds,Shane Neph,Richard Humbert,R. Scott Hansen,Marella F. T. R. de Bruijn,Licia Selleri,Alexander Y. Rudensky,Steven Z. Josefowicz,Robert M. Samstein,Evan E. Eichler,Stuart H. Orkin,Dana N. Levasseur,Thalia Papayannopoulou,Kai Hsin Chang,Arthur I. Skoultchi,Srikanta Gosh,Christine M. Disteche,Piper M. Treuting,Yanli Wang,Mitchell J. Weiss,Gerd A. Blobel,Xiaoyi Cao,Sheng Zhong,Ting Wang,Peter J. Good,Rebecca F. Lowdon,Rebecca F. Lowdon,Leslie B. Adams,Leslie B. Adams,Xiao Qiao Zhou,Michael J. Pazin,Elise A. Feingold,Barbara J. Wold,James Taylor,Ali Mortazavi,Sherman M. Weissman,John A. Stamatoyannopoulos,Michael Snyder,Roderic Guigó,Thomas R. Gingeras,David M. Gilbert,Ross C. Hardison,Michael A. Beer,Bing Ren +145 more
TL;DR: The mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types as mentioned in this paper.
Journal ArticleDOI
FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation
Alice P. Tsang,Jane E. Visvader,C.Alexander Turner,Yuko Fujiwara,Yuko Fujiwara,Channing Yu,Mitchell J. Weiss,Merlin Crossley,Stuart H. Orkin,Stuart H. Orkin +9 more
TL;DR: Findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors.
Journal ArticleDOI
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.
TL;DR: An in vitro ES cell differentiation assay is used for the phenotypic analysis of targeted mutations affecting hematopoietic development and finds that arrested GATA-1(-)-definitive proerythroblasts express GATA target genes at normal levels, implying substantial interchangeability of GATA factors in vivo.
Journal ArticleDOI
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Christopher R. Vakoc,Danielle L. Letting,Danielle L. Letting,Nele Gheldof,Tomoyuki Sawado,M. A. Bender,Mark Groudine,Mitchell J. Weiss,Mitchell J. Weiss,Job Dekker,Gerd A. Blobel,Gerd A. Blobel +11 more
TL;DR: Using chromosome conformation capture (3C), it is shown that the hematopoietic transcription factor GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus control region (LCR) and thebeta-major globin promoter.