L
Louis C. Dore
Researcher at Howard Hughes Medical Institute
Publications - 25
Citations - 4651
Louis C. Dore is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 22, co-authored 25 publications receiving 3578 citations. Previous affiliations of Louis C. Dore include University of Pennsylvania & University of Chicago.
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Journal ArticleDOI
The dynamic N 1 -methyladenosine methylome in eukaryotic messenger RNA
Dan Dominissini,Dan Dominissini,Sigrid Nachtergaele,Sigrid Nachtergaele,Sharon Moshitch-Moshkovitz,Eyal Peer,Eyal Peer,Nitzan Kol,Moshe Shay Ben-Haim,Moshe Shay Ben-Haim,Qing Dai,Qing Dai,Ayelet Di Segni,Mali Salmon-Divon,Wesley C. Clark,Guanqun Zheng,Tao Pan,Oz Solomon,Oz Solomon,Eran Eyal,Vera Hershkovitz,Dali Han,Dali Han,Louis C. Dore,Louis C. Dore,Ninette Amariglio,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Chuan He,Chuan He +30 more
TL;DR: It is shown that m1A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production.
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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
Hengyou Weng,Huilin Huang,Huizhe Wu,Xi Qin,Boxuan Simen Zhao,Lei Dong,Hailing Shi,Jennifer R. Skibbe,Chao Shen,Chao Hu,Chao Hu,Yue Sheng,Yungui Wang,Yungui Wang,Mark Wunderlich,Bin Zhang,Louis C. Dore,Rui Su,Xiaolan Deng,Xiaolan Deng,Kyle Ferchen,Chenying Li,Chenying Li,Miao Sun,Zhike Lu,Xi Jiang,Guido Marcucci,James C. Mulloy,Jian-Hua Yang,Zhijian Qian,Minjie Wei,Chuan He,Jianjun Chen +32 more
TL;DR: The results reveal the SPI1-METTL14-MYB/MYC signaling axis in myelopoiesis and leukemogenesis and highlight the critical roles of METTL14 and m6A modification in normal and malignant hematopoiedis.
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Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation
Ki Jun Yoon,Francisca Rojas Ringeling,Caroline Vissers,Fadi Jacob,Michael J. Pokrass,Dennisse Jimenez-Cyrus,Yijing Su,Namshik Kim,Yunhua Zhu,Lily Zheng,Sunghan Kim,Xinyuan Wang,Louis C. Dore,Peng Jin,Sergi Regot,Xiaoxi Zhuang,Stefan Canzar,Chuan He,Guo Li Ming,Hongjun Song +19 more
TL;DR: It is shown that m6A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into postnatal stages and uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells.
Journal ArticleDOI
N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas
Ye Fu,Guan-Zheng Luo,Guan-Zheng Luo,Kai Chen,Kai Chen,Xin Deng,Xin Deng,Miao Yu,Miao Yu,Dali Han,Dali Han,Ziyang Hao,Ziyang Hao,Jianzhao Liu,Jianzhao Liu,Xingyu Lu,Xingyu Lu,Louis C. Dore,Louis C. Dore,Xiaocheng Weng,Xiaocheng Weng,Quanjiang Ji,Quanjiang Ji,Laurens Mets,Chuan He,Chuan He +25 more
TL;DR: A comprehensive analysis of the 6mA landscape in the genome of Chlamydomonas using new sequencing approaches finds that 6mA mainly locates at ApT dinucleotides around transcription start sites (TSS) with a bimodal distribution and appears to mark active genes.
Journal ArticleDOI
A GATA-1-regulated microRNA locus essential for erythropoiesis
Louis C. Dore,Julio D. Amigo,Camila O. dos Santos,Zhe Zhang,Xiaowu Gai,John W. Tobias,Duonan Yu,Alyssa M. Klein,Christine M. Dorman,Weisheng Wu,Ross C. Hardison,Barry H. Paw,Mitchell J. Weiss +12 more
TL;DR: A gene complementation strategy combined with microarray screening revealed a miRNA locus that is required for erythropoiesis and uncovered a new regulatory axis through which GATA-1 controls this process.