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Wei Xin Khong
Researcher at Tan Tock Seng Hospital
Publications - 24
Citations - 1399
Wei Xin Khong is an academic researcher from Tan Tock Seng Hospital. The author has contributed to research in topics: Plasmid & Enterovirus 71. The author has an hindex of 12, co-authored 21 publications receiving 1150 citations. Previous affiliations of Wei Xin Khong include National University of Singapore & Singapore Ministry of Health.
Papers
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Journal ArticleDOI
Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures.
Rachael Pung,Calvin J Chiew,Barnaby Edward Young,Sarah Chin,Mark I-Cheng Chen,Hannah E. Clapham,Alex R. Cook,Sebastian Maurer-Stroh,Sebastian Maurer-Stroh,Matthias Paul Han Sim Toh,Cuiqin Poh,Mabel Low,Joshua Lum,Valerie T J Koh,Tze M. Mak,Lin Cui,Raymond T. P. Lin,Derrick Heng,Yee Sin Leo,David C. Lye,Vernon J. Lee,Kai Qian Kam,Shirin Kalimuddin,Seow Yen Tan,Jiashen Loh,Koh Cheng Thoon,Shawn Vasoo,Shawn Vasoo,Wei Xin Khong,Nur Afidah Suhaimi,Sherlynn Jh Chan,Emma Zhang,Olivia Seen Huey Oh,Albert Ty,Charlene Tow,Yi Xian Chua,Wei Liang Chaw,Yixiang Ng,Farid Abdul-Rahman,Shafiq Sahib,Zheng Zhao,Cheryl Tang,Constance Low,Ee Hui Goh,Georgina Lim,Yan'an Hou,Imran Roshan,James Tan,Kelly Foo,Khine Nandar,Lalitha Kurupatham,Pei Pei Chan,Pream Raj,Yijun Lin,Zubaidah Said,Anne Lee,Cherie See,Jessey Markose,Joanna Tan,Guanhao Chan,Wanhan See,Xinyi Peh,Vincent Cai,Wen Kai Chen,Zongbin Li,Roy Jiunn Jye Soo,Angela Lp Chow,Wycliffe E. Wei,Aysha Farwin,Li Wei Ang +69 more
TL;DR: SARS-CoV-2 is transmissible in community settings, and local clusters of COVID-19 are expected in countries with high travel volume from China before the lockdown of Wuhan and institution of travel restrictions.
Journal ArticleDOI
Interrupting transmission of COVID-19: lessons from containment efforts in Singapore.
TL;DR: Despite multiple importations resulting in local chains of transmission, Singapore has been able to control the COVID-19 outbreak without major disruption to daily living as mentioned in this paper, and share some early lessons learnt from the experience.
Journal ArticleDOI
A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection.
Wei Xin Khong,Benedict Yan,Huimin Yeo,Eng Lee Tan,Jia Jun Lee,Jowin K. W. Ng,Vincent T. K. Chow,Sylvie Alonso +7 more
TL;DR: It is demonstrated that 2-week-old and younger immunodeficient AG129 mice, which lack type I and II interferon receptors, are susceptible to infection with a non-mouse-adapted EV71 strain via both the intraperitoneal (i.p.) and oral routes of inoculation, making this mouse model relevant for EV71 pathogenesis studies and an attractive platform for EV 71 vaccine and drug testing.
Journal ArticleDOI
Sustained High Levels of Interleukin-6 Contribute to the Pathogenesis of Enterovirus 71 in a Neonate Mouse Model
TL;DR: It is demonstrated that IL-6 plays a major role in EV71-induced immunopathogenesis and as there is still neither vaccine nor treatment available against EV71, anti-IL-6 antibody treatment represents a potential therapeutic approach to providing protection from the most severe complications of the disease.
Journal ArticleDOI
Clinical and Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Adult Inpatients in Singapore.
Kalisvar Marimuthu,Kalisvar Marimuthu,Indumathi Venkatachalam,Wei Xin Khong,Tse Hsien Koh,Benjamin Pei Zhi Cherng,My Van La,Partha Pratim De,Partha Pratim De,Prabha Krishnan,Prabha Krishnan,Prabha Krishnan,Thean Yen Tan,Raymond Fong Kok Choon,Surinder Pada,Choong Weng Lam,Say Tat Ooi,Rama Narayana Deepak,Nares Smitasin,Eng Lee Tan,Jia Jun Lee,Asok Kurup,Barnaby Edward Young,Nancy Tee Wen Sim,Koh Cheng Thoon,Koh Cheng Thoon,Dale Fisher,Moi Lin Ling,Brenda Ang Sze Peng,Brenda Ang Sze Peng,Yik Ying Teo,Li Yang Hsu,Li Yang Hsu,Raymond T. P. Lin,Rick Twee-Hee Ong,Jeanette W. P. Teo,Oon Tek Ng,Oon Tek Ng +37 more
TL;DR: Clinical CRE trend among adult inpatients showed stabilization following a rapid rise since introduction in 2010 potentially due to infection prevention measures and antimicrobial stewardship.